Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice,Journal of Agricultural and Food Chemistry

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Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-08-30 00:00:00 , DOI: 10.1021/acs.jafc.8b03568
Li Yuan ₁ , Xueyi Li ₁ , Shenyuan He ₁ , Chunxia Gao ₁ , Chengtao Wang ₂ , Yuyu Shao ₁

Affiliation

Isoorientin (ISO) is a natural flavonoid, which is a 6-C-glucoside of luteolin, and has been demonstrated to possess multiple biological properties. In this study, the effects of ISO on the growth performance and gut microbiota of BALB/c mice were investigated. The results showed that ISO could promote food intake and body weight gain, increase the digestibility of crude proteins and utilization of the gross energy, and strengthen antioxidant capacity of mice. We also demonstrated it has no side effects on hepatic and renal functions. Moreover, ISO inhibited the growth of most bacteria in gut microbiota, especially the pathogenic genera of Alistipes, Helicobacter, and Oscillibacter, which could lead to inflammation. Metabolisms of epithelial cell signaling in Helicobacter pylori infection, lipopolysaccharide (LPS) biosynthesis, and LPS biosynthesis proteins in gut microbiota of the control group were more abundant than those in the ISO group, while lipid metabolism and vitamin B₆ metabolism were enriched in the ISO group. We found the changes in enrichments of metabolic pathways of the gut microbiota along with the ISO application were positively correlated with the antioxidation, anti-inflammation, and antibiosis. This work provided a fundamental basis for the future development of ISO-functional foods used for resistance to oxidation, inflammation, and pathogens.

中文翻译：

天然类黄酮异orientin对小鼠生长性能和肠道菌群的影响

异Orientinin（ISO）是天然的类黄酮，它是木犀草素的6 C-葡萄糖苷，并已证明具有多种生物学特性。在这项研究中，研究了ISO对BALB / c小鼠生长性能和肠道菌群的影响。结果表明，ISO可以促进食物的摄入和体重的增加，增加粗蛋白的消化率和总能量的利用，并增强小鼠的抗氧化能力。我们还证明了它对肝和肾功能没有副作用。此外，ISO还抑制了肠道菌群中大多数细菌的生长，特别是阿利培斯，幽门螺杆菌和Oscillibacter的致病菌属。，这可能导致发炎。对照组肠道菌群中幽门螺杆菌感染，脂多糖（LPS）生物合成和LPS生物合成蛋白的上皮细胞信号代谢比ISO组更丰富，而脂质代谢和维生素B ₆代谢在ISO中更丰富。团体。我们发现肠道菌群代谢途径的富集变化以及ISO的应用与抗氧化，抗炎症和抗生物活性呈正相关。这项工作为将来开发用于抵抗氧化，炎症和病原体的具有ISO功能的食品提供了基础。

更新日期：2018-08-30

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