B(C6F5)3-Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane,The Journal of Organic Chemistry

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B(C6F5)3-Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-08-29 00:00:00 , DOI: 10.1021/acs.joc.8b01362
Zhentao Pan ₁ , Leixin Shen ₁ , Dingguo Song ₁ , Zhen Xie ₁ , Fei Ling ₁ , Weihui Zhong ₁

Affiliation

The first example of metal-free B(C₆F₅)₃-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81–95% yield with 80–99% de. This protocol was further applied in the total synthesis of cinacalcet.

中文翻译：

B（C ₆ F ₅）_3-氨硼烷催化的酮不对称还原胺化

报道了使用氨硼烷作为还原剂，用手性α-甲基苄胺（α-MBA）进行的无金属的B（C ₆ F ₅）₃催化的酮的不对称还原胺化的第一个实例。这种一锅法具有广泛的底物范围，并以81-95％的收率和80-99％的de提供了各种手性胺。该方案进一步应用于西那卡塞的全合成中。

更新日期：2018-08-29

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