用于牙周再生的组织工程构建体：现状和未来展望,Advanced Healthcare Materials

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用于牙周再生的组织工程构建体：现状和未来展望
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-08-26 , DOI: 10.1002/adhm.201800457
Cedryck Vaquette _{1,

2,

3} , Sophia P. Pilipchuk _{4,

5} , P. Mark Bartold ₆ , Dietmar W. Hutmacher _{1,

2} , William V. Giannobile _{4,

5} , Saso Ivanovski ₃

Affiliation

牙周膜由牙龈，牙周膜韧带，牙骨质和牙槽骨组成，是一个层次分明的组织，其主要作用是为牙齿提供物理和机械支持。严重的牙周炎病例是由口腔细菌生物膜引发的炎症，可导致牙周软组织和硬组织的严重破坏，并导致牙齿功能和美观受损。尽管当前的治疗方法可以通过控制炎症方面来限制疾病的进展，但是无法预期地实现完整的牙周再生。研究了各种组织工程学方法，它们控制关键的颞空伤口愈合事件的能力，这些对于实现牙周再生至关重要。本文回顾了牙周组织工程领域的最新进展，重点是先进的3D多相组织工程构造（TEC），并对它们的再生潜力和局限性进行了重要分析。审查还详细阐述了牙周组织工程的未来，包括针对个别牙周缺损的支架定制，TEC赋予增强生物活性的功能化策略，牙周韧带纤维引导以及利用可促进临床翻译的椅旁再生液。

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Tissue Engineered Constructs for Periodontal Regeneration: Current Status and Future Perspectives

The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved. Various tissue engineering approaches are investigated for their ability to control the critical temporo‐spatial wound healing events that are essential for achieving periodontal regeneration. This paper reviews recent progress in the field of periodontal tissue engineering with an emphasis on advanced 3D multiphasic tissue engineering constructs (TECs) and provides a critical analysis of their regenerative potential and limitations. The review also elaborates on the future of periodontal tissue engineering, including scaffold customization for individual periodontal defects, TEC's functionalization strategies for imparting enhanced bioactivity, periodontal ligament fiber guidance, and the utilization of chair‐side regenerative solutions that can facilitate clinical translation.

更新日期：2018-08-26

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