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The development of the dorsal mesentery in human embryos and fetuses.
Seminars in Cell & Developmental Biology ( IF 6.2 ) Pub Date : 2018-08-25 , DOI: 10.1016/j.semcdb.2018.08.009
Jill P J M Hikspoors 1 , Nutmethee Kruepunga 1 , Greet M C Mommen 1 , Jean-Marie P W U Peeters 1 , Cindy J M Hülsman 1 , S Eleonore Köhler 1 , Wouter H Lamers 1
Seminars in Cell & Developmental Biology ( IF 6.2 ) Pub Date : 2018-08-25 , DOI: 10.1016/j.semcdb.2018.08.009
Jill P J M Hikspoors 1 , Nutmethee Kruepunga 1 , Greet M C Mommen 1 , Jean-Marie P W U Peeters 1 , Cindy J M Hülsman 1 , S Eleonore Köhler 1 , Wouter H Lamers 1
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The vertebrate intestine has a continuous dorsal mesentery between pharynx and anus that facilitates intestinal mobility. Based on width and fate the dorsal mesentery can be subdivided into that of the caudal foregut, midgut, and hindgut. The dorsal mesentery of stomach and duodenum is wide and topographically complex due to strong and asymmetric growth of the stomach. The associated formation of the lesser sac partitions the dorsal mesentery into the right-sided "caval fold" that serves as conduit for the inferior caval vein and the left-sided mesogastrium. The thin dorsal mesentery of the midgut originates between the base of the superior and inferior mesenteric arteries, and follows the transient increase in intestinal growth that results in small-intestinal looping, intestinal herniation and, subsequently, return. The following fixation of a large portion of the abdominal dorsal mesentery to the dorsal peritoneal wall by adhesion and fusion is only seen in primates and is often incomplete. Adhesion and fusion of mesothelial surfaces in the lesser pelvis results in the formation of the "mesorectum". Whether Toldt's and Denonvilliers' "fasciae of fusion" identify the location of the original mesothelial surfaces or, alternatively, represent the effects of postnatal wear and tear due to intestinal motility and intra-abdominal pressure changes, remains to be shown. "Malrotations" are characterized by growth defects of the intestinal loops with an ischemic origin and a narrow mesenteric root due to insufficient adhesion and fusion.
中文翻译:
人类胚胎和胎儿背膜的发育。
脊椎动物小肠在咽和肛门之间具有连续的背肠系膜,有利于小肠的活动。根据宽度和命运,可以将背肠系膜细分为尾前肠,中肠和后肠。胃和十二指肠的背面肠系膜由于胃的强壮和不对称生长而很宽且在地形上很复杂。小囊的相关形成将背肠系膜分隔成右侧“腔褶”,该“腔褶”用作下腔静脉和左侧中肠胃的导管。中肠的薄背肠系膜起源于肠系膜上动脉和下肠动脉的底部之间,并随着肠管生长的短暂增加而导致小肠弯曲,肠管疝和随后的回肠。随后通过粘附和融合将大部分腹部背膜肠系膜固定在背腹膜壁上的现象仅在灵长类动物中可见,并且通常是不完全的。间皮表面在小骨盆中的粘附和融合导致“肠系膜”的形成。Toldt和Denonvilliers的“融合筋膜”是确定原始间皮表面的位置,还是代表肠蠕动和腹内压力变化引起的产后磨损的影响,仍有待观察。“旋转不良”的特征是由于粘连和融合不充分而具有缺血起源和肠系膜根部狭窄的肠loop生长缺陷。
更新日期:2018-08-25
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
人类胚胎和胎儿背膜的发育。
脊椎动物小肠在咽和肛门之间具有连续的背肠系膜,有利于小肠的活动。根据宽度和命运,可以将背肠系膜细分为尾前肠,中肠和后肠。胃和十二指肠的背面肠系膜由于胃的强壮和不对称生长而很宽且在地形上很复杂。小囊的相关形成将背肠系膜分隔成右侧“腔褶”,该“腔褶”用作下腔静脉和左侧中肠胃的导管。中肠的薄背肠系膜起源于肠系膜上动脉和下肠动脉的底部之间,并随着肠管生长的短暂增加而导致小肠弯曲,肠管疝和随后的回肠。随后通过粘附和融合将大部分腹部背膜肠系膜固定在背腹膜壁上的现象仅在灵长类动物中可见,并且通常是不完全的。间皮表面在小骨盆中的粘附和融合导致“肠系膜”的形成。Toldt和Denonvilliers的“融合筋膜”是确定原始间皮表面的位置,还是代表肠蠕动和腹内压力变化引起的产后磨损的影响,仍有待观察。“旋转不良”的特征是由于粘连和融合不充分而具有缺血起源和肠系膜根部狭窄的肠loop生长缺陷。