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Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes
Current Opinion in Virology ( IF 5.7 ) Pub Date : 2018-08-23 , DOI: 10.1016/j.coviro.2018.08.001
Alexander Borodavka , Ulrich Desselberger , John T Patton

Segmented double-stranded (ds)RNA viruses share remarkable similarities in their replication strategy and capsid structure. During virus replication, positive-sense single-stranded (+)RNAs are packaged into procapsids, where they serve as templates for dsRNA synthesis, forming progeny particles containing a complete equimolar set of genome segments. How the +RNAs are recognized and stoichiometrically packaged remains uncertain. Whereas bacteriophages of the Cystoviridae family rely on specific RNA–protein interactions to select appropriate +RNAs for packaging, viruses of the Reoviridae instead rely on specific inter-molecular interactions between +RNAs that guide multi-segmented genome assembly. While these families use distinct mechanisms to direct +RNA packaging, both yield progeny particles with a complete set of genomic dsRNAs.



中文翻译:

多节段dsRNA病毒中的基因组包装:具有相似结果的不同机制

分段的双链(ds)RNA病毒在其复制策略和衣壳结构方面有着惊人的相似之处。在病毒复制过程中,将正义单链(+)RNA包装到衣壳中,在其中作为dsRNA合成的模板,形成包含完整等摩尔基因组片段的子代颗粒。+ RNA的识别和化学计量包装的方式仍然不确定。Cystoviridae家族的噬菌体依靠特定的RNA-蛋白质相互作用来选择合适的+ RNA进行包装,而呼肠孤病毒科的病毒相反,它依赖于+ RNA之间的特定分子间相互作用,该相互作用指导多节段基因组组装。尽管这些家族使用不同的机制来指导+ RNA的包装,但它们均产生具有完整的基因组dsRNA集的子代颗粒。

更新日期:2018-08-23
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