Synthesis of Redox-Responsive Core Cross-Linked Micelles Carrying Optically Active Helical Poly(phenyl isocyanide) Arms and Their Applications in Drug Delivery,ACS Macro Letters

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Synthesis of Redox-Responsive Core Cross-Linked Micelles Carrying Optically Active Helical Poly(phenyl isocyanide) Arms and Their Applications in Drug Delivery
ACS Macro Letters ( IF 5.1 ) Pub Date : 2018-08-20 00:00:00 , DOI: 10.1021/acsmacrolett.8b00610
Song-Qing Zhao ₁ , Guiju Hu ₁ , Xun-Hui Xu ₁ , Shu-Ming Kang ₁ , Na Liu ₁ , Zong-Quan Wu ₁

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In this manuscript, we designed and synthesized three core cross-linked micelles (M-5L, P-5L, and P-5D) with redox-responsive disulfide bonds in the core and carrying optically active helical polyisocyanide arms. Their arms were different in the helicity of the main chain and the chirality of the side groups. These micelles showed excellent redox-responsiveness to reducing agent. However, because of the different chiralities of the arms, the three micelles exhibited different performances in drug delivery and controlled release. The M-5L micelle carrying left-handed helical arms showed better therapeutic effect than the other two due to the rapid cell membrane permeability.

中文翻译：

带有光学活性螺旋多（苯基异氰）臂的氧化还原反应核心交联胶束的合成及其在药物输送中的应用

在这份手稿中，我们设计并合成了三个核心交联胶束（M - 5L、P - 5L和P - 5D），其核心具有氧化还原响应性二硫键，并带有光学活性的螺旋多异氰化物臂。它们的臂在主链的螺旋度和侧基的手性方面有所不同。这些胶束对还原剂表现出优异的氧化还原反应性。然而，由于臂的不同手性，三种胶束在药物递送和控释方面表现出不同的表现。M - 5L _由于细胞膜通透性快，携带左旋螺旋臂的胶束显示出比其他两种更好的治疗效果。

更新日期：2018-08-20

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