Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions,Chemistry - A European Journal

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Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-08-19 , DOI: 10.1002/chem.201803064
Thomas C Stephens ₁ , Aggie Lawer ₁ , Thomas French ₁ , William P Unsworth ₁

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Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3‐ or 4‐atom iterative ring expansion protocol. The products can also be expanded using amino acid‐based linear fragments, meaning that macrocycles with precise sequences of hydroxy‐ and amino acids can be assembled in high yields by “growing” them from smaller rings, using a simple procedure in which high dilution is not required. The method should significantly expedite the practical synthesis of diverse nitrogen containing macrolide frameworks.

中文翻译：

使用连续扩环反应迭代组装大环内酯

大环内酯可以通过有效的 3 或 4 原子迭代扩环方案由内酰胺和羟基酸衍生物制备。该产品还可以使用基于氨基酸的线性片段进行扩展，这意味着具有精确的羟基和氨基酸序列的大环化合物可以通过从较小的环“生长”它们来高产量地组装，使用一个简单的程序，其中高度稀释不需要。该方法应显着加快多种含氮大环内酯骨架的实际合成。

更新日期：2018-08-19

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