Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma.

中文翻译：

---

BAFF / APRIL受体脱落控制B细胞

BCMA，TACI和BAFFR受体的蛋白水解作用降低了它们的细胞表面表达以及B细胞亚群的配体介导的存活率。该脱落通过蛋白酶γ-分泌酶或金属蛋白酶来执行，并且部分取决于配体结合和受体相互作用。脱落的受体可以作为自身免疫和淋巴瘤的生物标志物。