The researchers analysed cell lines from different sources, including the popular MCF7 type used to investigate cancer. They found a staggering amount of variation. Supposedly identical cell lines were actually far from identical — there were differences in their genomes, gene expression, morphology and, importantly, drug sensitivity. This could help to explain why so many experimental results that rely on the standard performance of a specific cell line can’t be reproduced.

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研究人员分析了来自不同来源的细胞系，包括流行的用于研究癌症的MCF7类型。他们发现了惊人的变化。假设相同的细胞系实际上并非完全相同-它们的基因组，基因表达，形态和重要的是药物敏感性存在差异。这可能有助于解释为什么不能复制如此多依赖特定细胞系标准性能的实验结果。