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Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-08-13 , DOI: 10.1002/adfm.201802140
Xiaokang Ding 1 , Shun Duan 1 , Xuejia Ding 1 , Runhui Liu 2 , Fu-Jian Xu 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-08-13 , DOI: 10.1002/adfm.201802140
Xiaokang Ding 1 , Shun Duan 1 , Xuejia Ding 1 , Runhui Liu 2 , Fu-Jian Xu 1
Affiliation
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Antibacterial materials that prevent bacterial infections and mitigate bacterial virulence have attracted great scientific interests. In recent decades, the bactericidal polymers have been presented as promising candidates to combat bacterial pathogens, mainly based on the construction of bactericidal cationic polymers, functionalization with biocidal agents, and formation of bacterial‐repelling layers. However, these established strategies have inherent disadvantages because they often overlook important features such as their biocompatibility and biosafety, especially for biomedical applications. In recent years, many efforts have been made focusing on the development of multifunctional antibacterial materials to meet the elaborate requirements for medical devices and public hygiene products. Herein the recent advances in developing multifunctional materials for their antibacterial activities together with other functions including “kill‐and‐release” capability, hemocompatibility, cell proliferation promoting properties, and coagulation promoting ability for wound dressing are highlighted. In addition, the outlooks on the remaining challenges that should be addressed in the field of multifunctional antibacterial materials are also described.
中文翻译：
多功能抗菌材料：对抗细菌病原体的新兴武器库
预防细菌感染并减轻细菌毒力的抗菌材料引起了极大的科学兴趣。近几十年来，杀菌聚合物被认为是对抗细菌病原体的有前途的候选者，主要是基于杀菌阳离子聚合物的构建，杀菌剂的功能化以及细菌排斥层的形成。但是，这些既定策略具有固有的弊端，因为它们常常忽略了重要特征，例如其生物相容性和生物安全性，特别是对于生物医学应用而言。近年来，为满足对医疗器械和公共卫生产品的详细要求，已经进行了许多努力来致力于多功能抗菌材料的开发。本文重点介绍了开发具有抗菌活性的多功能材料以及其他功能的最新进展，这些功能包括“杀伤和释放”功能，血液相容性，促进细胞增殖的特性以及促进伤口包扎的凝血功能。另外，还描述了在多功能抗菌材料领域应解决的剩余挑战的前景。
更新日期：2018-08-13
中文翻译：
多功能抗菌材料：对抗细菌病原体的新兴武器库
预防细菌感染并减轻细菌毒力的抗菌材料引起了极大的科学兴趣。近几十年来，杀菌聚合物被认为是对抗细菌病原体的有前途的候选者，主要是基于杀菌阳离子聚合物的构建，杀菌剂的功能化以及细菌排斥层的形成。但是，这些既定策略具有固有的弊端，因为它们常常忽略了重要特征，例如其生物相容性和生物安全性，特别是对于生物医学应用而言。近年来，为满足对医疗器械和公共卫生产品的详细要求，已经进行了许多努力来致力于多功能抗菌材料的开发。本文重点介绍了开发具有抗菌活性的多功能材料以及其他功能的最新进展，这些功能包括“杀伤和释放”功能，血液相容性，促进细胞增殖的特性以及促进伤口包扎的凝血功能。另外，还描述了在多功能抗菌材料领域应解决的剩余挑战的前景。
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