Cover Feature: Exploiting the Catalytic Diversity of Short‐Chain Dehydrogenases/Reductases: Versatile Enzymes from Plants with Extended Imine Substrate Scope (ChemBioChem 17/2018),ChemBioChem

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Cover Feature: Exploiting the Catalytic Diversity of Short‐Chain Dehydrogenases/Reductases: Versatile Enzymes from Plants with Extended Imine Substrate Scope (ChemBioChem 17/2018)
ChemBioChem ( IF 2.6 ) Pub Date : 2018-08-13 , DOI: 10.1002/cbic.201800455
Sebastian Roth ₁ , Matthew B. Kilgore ₂ , Toni M. Kutchan ₂ , Michael Müller ₁

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The cover feature picture shows the plant Narcissus pseudonarcissus, which contains the enzyme noroxomaritidine reductase (NR). This member of the short‐chain dehydrogenase/reductase (SDR) family serves as an enone reductase in Amaryllidaceae alkaloid biosynthesis. We have found NR to be active with a set of typical imine substrates, thus demonstrating that SDRs are suitable for biocatalytic C=N reduction. Moreover, NR accepts keto substrates as well, thereby highlighting the enzyme family′s versatility. With NR as a template, we have identified a novel imine‐reducing SDR. More information can be found in the communication by M. Müller et al. on page 1849 in Issue 17, 2018 (DOI: 10.1002/cbic.201800291).

中文翻译：

封面功能：利用短链脱氢酶/还原酶的催化多样性：具有扩展的亚胺底物范围的植物的多种酶（ChemBioChem 17/2018）

封面特征图片显示了植物Narcissus pseudonarcissus，其中含有Noroxomaritidine还原酶（NR）。短链脱氢酶/还原酶（SDR）家族的这个成员在金莲花科生物碱生物合成中用作烯酮还原酶。我们发现NR对一组典型的亚胺底物具有活性，因此证明SDR适用于生物催化的C = N还原。此外，NR还接受酮基底物，从而突出了酶家族的多功能性。以NR为模板，我们确定了一种新型的减少亚胺的SDR。在M.Müller等人的来文中可以找到更多信息。就在第17期，1849年2018页（：10.1002 / cbic.201800291 DOI）。

更新日期：2018-08-13

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