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Synthesis of Enantioenriched Bromohydrins via Divergent Reactions of Racemic Intermediates from Anchimeric Oxygen Borrowing
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-08-13 , DOI: 10.1021/jacs.8b06432
Yi-Ming Cao 1 , Dieter Lentz 1 , Mathias Christmann 1
Affiliation  

We report a chiral phosphoric acid catalyzed bromocyclization/regiodivergent reaction of racemic intermediates sequence, which is enabled by anchimeric oxygen borrowing. Different types of alkenes are applicable, and both enantiomers of the bromohydrin products were obtained in generally excellent yields and enantioselectivities. In addition, an example of enantioconvergent synthesis from the two isomeric products is presented.

中文翻译:

通过嵌合氧借用外消旋中间体的发散反应合成对映体富集的溴醇

我们报告了一种手性磷酸催化的外消旋中间体序列的溴环化/区域发散反应,这是通过嵌合氧借用实现的。可以使用不同类型的烯烃,并且溴代醇产物的两种对映异构体通常都以优异的产率和对映选择性获得。此外,还介绍了从两种异构体产物对映聚合合成的例子。
更新日期:2018-08-13
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