Duplications at the 15q11.2-q13.1 region are associated with psychiatric disorders such as developmental delay and autism spectrum disorder. However, the specific influence of these duplications on human neuronal cells remains unclear. Here we generated induced pluripotent stem cells (iPSCs) derived from a patient with 15q11.2-q13.1 duplication syndrome. The generated iPSCs carried 15q11.2-q13.1 duplication and showed typical iPSC morphology and pluripotency marker expression, and the capacity to differentiate into three germ layers. These iPSC lines will contribute to further understanding the pathology of 15q11.2-q13.1 duplication syndrome and help develop drugs to treat psychiatric disorders.

15q11.2-q13.1区域的重复与精神疾病有关，例如发育迟缓和自闭症谱系障碍。但是，这些重复对人类神经元细胞的具体影响尚不清楚。在这里，我们产生了来自15q11.2-q13.1复制综合征患者的诱导多能干细胞（iPSC）。生成的iPSC进行15q11.2-q13.1重复，并显示出典型的iPSC形态和多能性标记表达，并具有分化为三个胚层的能力。这些iPSC系列产品将有助于进一步了解15q11.2-q13.1复制综合征的病理，并有助于开发治疗精神疾病的药物。