Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications,Crystal Growth & Design

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Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2018-08-10 00:00:00 , DOI: 10.1021/acs.cgd.8b00933
Maryam Karimi-Jafari ₁ , Luis Padrela ₁ , Gavin M. Walker ₁ , Denise M. Croker ₁

Affiliation

Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification of cocrystal research efforts has been accompanied by an expansion of the potential applications where cocrystals can offer a benefit. Where once solubility manipulation was seen as the primary driver for cocrystal formation, cocrystals have recently been shown to provide attractive options for taste masking, mechanical property improvement, and intellectual property generation and extension. Cocrystals are becoming a commercial reality with a number of cocrystal products currently on the market and more following in registration and clinical trial phases. Increased commercialization of cocrystals has in turn necessitated additional research on methods to make cocrystals, with particular emphasis placed on emerging technologies that can offer environmentally attractive and efficient options. Methods of producing cocrystals and of harnessing the bespoke physical property adjustment provided by cocrystals are reviewed in this article, with a particular focus on emerging trends in these areas.

中文翻译：

创建共晶体：药物共晶体制备途径和应用的回顾

共晶最初发现于一个多世纪前，由于其能够改变固态材料（尤其是药物）的物理特性的能力，在现代社会中继续引起人们的兴趣。随着共晶体研究工作的加强，伴随着潜在应用的扩展，共晶体可以带来好处。在曾经将溶解度控制视为共晶形成的主要驱动力的地方，最近发现共晶为掩味，机械性能改善以及知识产权的产生和扩展提供了有吸引力的选择。随着目前市场上的许多共晶产品以及在注册和临床试验阶段的更多应用，共晶正成为商业现实。共晶体商业化的增加反过来又需要对制造共晶体的方法进行更多的研究，特别是将重点放在可以提供对环境有吸引力和有效的选择的新兴技术上。本文对共晶的生产方法以及利用共晶提供的定制物理性能进行了综述，其中特别关注了这些领域的新兴趋势。

更新日期：2018-08-10

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