Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions,The Journal of Organic Chemistry

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Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-08-09 00:00:00 , DOI: 10.1021/acs.joc.8b01730
Yuxuan Ding ₁ , Shihui Luo ₁ , Adila Adijiang ₁ , Hongye Zhao ₁ , Jie An ₁

Affiliation

The first general reductive deuteration of nitriles under single-electron transfer conditions has been developed for the synthesis of α,α-dideuterio amines. This practical and cost-efficient protocol requires only bench stable and commercially available sodium dispersions and EtOD-d₁ and allows for the reductive deuteration of a variety of nitriles in excellent yields and deuterium incorporations.

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