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Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-08-10 , DOI: 10.1021/acsami.8b09596 Soojeong Cho 1 , Byeongdu Lee 2 , Wooram Park 1 , Xiaoke Huang 1 , Dong-Hyun Kim 1, 3
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-08-10 , DOI: 10.1021/acsami.8b09596 Soojeong Cho 1 , Byeongdu Lee 2 , Wooram Park 1 , Xiaoke Huang 1 , Dong-Hyun Kim 1, 3
Affiliation
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Nanoradiosensitizers have been developed to enhance localization and precision of therapeutic radiation delivery. A specific volume of comprising surface atoms is known to be the radiosensitizing region. However, the shape-dependent local dose enhancement of nanoparticles is often underestimated and rarely reported. Here, a noble metal nanostructure, inspired by the photoperiodic day-flowers, was synthesized by metal reduction with bile acid molecules. The impact of high surface area of day-flower mimicking metallic nanoparticles (D-NP) on radiosensitizing effect was demonstrated with assays for ROS generation, cellular apoptosis, and clonogenic survival of human liver cancer cells (HepG2) cells. In comparison with lower-surface-area spherical night-flower mimicking metallic nanoparticles (N-NP), exposure of our D-NP to external beam radiation doses led to a significant increase in reactive oxygen species (ROS) production and radiosensitizing cell cycle synchronization, resulting in an enhanced cancer-cell-killing effect. In clonogenic survival studies, dose-enhancing factor (DEF) of D-NP was 16.5-fold higher than N-NP. Finally, we demonstrated in vivo feasibility of our D-NP as a potent nanoradiosensitizer and CT contrast agent for advanced image-guided radiation therapy.
中文翻译：
光周期花模仿金属纳米粒子的图像指导医学应用。
已经开发出纳米放射增敏剂以增强治疗性放射递送的定位和精确度。已知包括表面原子的特定体积是放射增感区。然而，纳米颗粒的形状依赖性局部剂量增加常常被低估并且很少被报道。在这里，受光周期日花的启发，通过用胆汁酸分子还原金属来合成贵金属纳米结构。通过人类肝癌细胞（HepG2）细胞的ROS生成，细胞凋亡和克隆形成存活率的测定，证明了日花模拟金属纳米颗粒（D-NP）的高表面积对放射增敏作用的影响。与模拟金属纳米粒子（N-NP）的较低表面积球形夜花相比，我们的D-NP暴露于外部射线辐射剂量导致活性氧（ROS）产生和放射增敏细胞周期同步性显着增加，从而增强了癌细胞杀伤作用。在克隆生存研究中，D-NP的剂量增强因子（DEF）比N-NP高16.5倍。最后，我们证明了D-NP作为有效的纳米放射增敏剂和CT造影剂用于先进的图像引导放射治疗的体内可行性。
更新日期：2018-08-07
中文翻译：
光周期花模仿金属纳米粒子的图像指导医学应用。
已经开发出纳米放射增敏剂以增强治疗性放射递送的定位和精确度。已知包括表面原子的特定体积是放射增感区。然而，纳米颗粒的形状依赖性局部剂量增加常常被低估并且很少被报道。在这里，受光周期日花的启发，通过用胆汁酸分子还原金属来合成贵金属纳米结构。通过人类肝癌细胞（HepG2）细胞的ROS生成，细胞凋亡和克隆形成存活率的测定，证明了日花模拟金属纳米颗粒（D-NP）的高表面积对放射增敏作用的影响。与模拟金属纳米粒子（N-NP）的较低表面积球形夜花相比，我们的D-NP暴露于外部射线辐射剂量导致活性氧（ROS）产生和放射增敏细胞周期同步性显着增加，从而增强了癌细胞杀伤作用。在克隆生存研究中，D-NP的剂量增强因子（DEF）比N-NP高16.5倍。最后，我们证明了D-NP作为有效的纳米放射增敏剂和CT造影剂用于先进的图像引导放射治疗的体内可行性。
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