Although some diazo compounds have bioactivities of medicinal interest, little is known about diazo group formation in nature. Here we describe an unprecedented nitrous acid biosynthetic pathway responsible for the formation of a diazo group in the biosynthesis of the ortho-diazoquinone secondary metabolite cremeomycin in Streptomyces cremeus. This finding provides important insights into the biosynthetic pathways not only for diazo compounds but also for other naturally occurring compounds containing nitrogen-nitrogen bonds.

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用于细菌中重氮基团形成的亚硝酸生物合成途径

尽管一些重氮化合物具有医学上的生物活性，但人们对自然界中重氮基团的形成知之甚少。在这里，我们描述了史无前例的亚硝酸生物合成途径，负责在链霉菌链霉菌中邻二氮杂醌次生代谢霉素霉素的生物合成中形成重氮基团。这一发现不仅对重氮化合物的生物合成途径提供了重要的见解，而且对含有氮-氮键的其他天然存在的化合物的生物合成途径也提供了重要的见识。