A 77-year-old man of Asian descent with chronic stage 3 kidney disease, gout, and hypertension was admitted with 3 days of fever, myalgia, and cutaneous eruption. On examination he was febrile to 102.3°F and had a diffuse maculopapular eruption over his trunk and arms. Initial laboratory results indicated leukopenia with mild eosinophilia and alanine aminotransferase and aspartate aminotransferase levels of 308 U/L and 248 U/L, respectively. He had been prescribed allopurinol, 300 mg daily, and colchicine, 0.6 mg daily, 1 month earlier given frequent attacks of acute gouty arthritis. Drug rash with eosinophilia and systemic symptoms (DRESS) was suspected and allopurinol was discontinued. Blood testing for HLA-B*5801 by polymerase chain reaction had a positive result. Despite steroid therapy his condition worsened, and his course was complicated by bronchiolitis, acute kidney injury, and small bowel perforation requiring multiple abdominal surgeries. He was discharged after more than 2 months in the hospital.

一名患有亚洲人血统的77岁男子患有慢性3期肾病，痛风和高血压，因发烧，肌痛和皮疹3天而入院。经检查，他的体温升至102.3°F，并在躯干和手臂上散布了斑丘疹。最初的实验室结果表明白细胞减少症伴有轻度嗜酸性粒细胞增多，丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平分别为308 U / L和248 U / L。由于急性痛风性关节炎的频繁发作，他于1个月前服用别嘌呤醇（每天300 mg）和秋水仙碱（每天0.6 mg）的处方。怀疑患有嗜酸性粒细胞增多和全身症状（DRESS）的皮疹，并停用别嘌醇。HLA-B * 5801的血液测试通过聚合酶链反应产生了积极的结果。尽管进行了类固醇治疗，他的病情仍在恶化，并且其病程并发着毛细支气管炎，急性肾损伤和小肠穿孔，需要进行多次腹部手术。他在医院超过两个月后出院。