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DBU-Catalyzed Desymmetrization of Cyclohexadienones: Access to Vicinal Diamine-Containing Heterocycles
Organic Letters ( IF 4.9 ) Pub Date : 2018-08-03 00:00:00 , DOI: 10.1021/acs.orglett.8b02158
Hongxing Jin 1 , Changhang Dai 1 , You Huang 1, 2
Affiliation  

A DBU-catalyzed desymmetrization strategy between cyclohexadienones and isocyanates was discovered, affording a series of vicinal diamine-containing heterocycle derivatives in moderate to good yields and excellent diastereoselectivity under mild conditions. Furthermore, this reaction could be performed on a 10 g scale using 1.0 mol % of catalyst loading.

中文翻译:

DBU催化的环己二酮的不对称化:获得含邻二胺的杂环。

发现了一种在环己二烯酮和异氰酸酯之间的DBU催化的脱对称策略,从而在温和条件下以中等至良好的收率和优异的非对映选择性提供了一系列含邻位二胺的杂环衍生物。此外,该反应可以使用1.0mol%的催化剂负载量以10g规模进行。
更新日期:2018-08-03
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