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Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.
Cell Reports ( IF 7.5 ) Pub Date : 2018-07-31 , DOI: 10.1016/j.celrep.2018.06.075
Ioannis D Dimitriou 1 , Korris Lee 1 , Itoro Akpan 2 , Evan F Lind 3 , Valarie A Barr 2 , Pamela S Ohashi 4 , Lawrence E Samelson 2 , Robert Rottapel 5
Cell Reports ( IF 7.5 ) Pub Date : 2018-07-31 , DOI: 10.1016/j.celrep.2018.06.075
Ioannis D Dimitriou 1 , Korris Lee 1 , Itoro Akpan 2 , Evan F Lind 3 , Valarie A Barr 2 , Pamela S Ohashi 4 , Lawrence E Samelson 2 , Robert Rottapel 5
Affiliation
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Successful anti-viral response requires the sustained activation and expansion of CD8+ T cells for periods that far exceed the time limit of physical T cell interaction with antigen-presenting cells (APCs). The expanding CD8+ T cell pool generates the effector and memory cell populations that provide viral clearance and long-term immunity, respectively. Here, we demonstrate that 3BP2 is recruited in cytoplasmic microclusters and nucleates a signaling complex that facilitates MHC:peptide-independent activation of signaling pathways downstream of the TCR. We show that induction of the adaptor molecule 3BP2 is a sensor of TCR signal strength and is critical for sustaining CD8+ T cell proliferation and regulating effector and memory differentiation.
中文翻译：
3BP2诱导的定时调节对于维持CD8 + T细胞的扩增和分化至关重要。
成功的抗病毒应答需要CD8 + T细胞持续活化和扩增，持续时间远远超过物理T细胞与抗原呈递细胞（APC）相互作用的时间限制。不断扩大的CD8 + T细胞池产生效应子和记忆细胞群，分别提供病毒清除和长期免疫力。在这里，我们证明了3BP2在细胞质微团簇中募集并成核了信号转导复合物，该复合物促进了TCR下游信号通路的MHC：肽非依赖性激活。我们表明，适配器分子3BP2的感应是TCR信号强度的传感器，对于维持CD8 + T细胞的增殖以及调节效应子和记忆的分化至关重要。
更新日期：2018-08-01
中文翻译：
3BP2诱导的定时调节对于维持CD8 + T细胞的扩增和分化至关重要。
成功的抗病毒应答需要CD8 + T细胞持续活化和扩增，持续时间远远超过物理T细胞与抗原呈递细胞（APC）相互作用的时间限制。不断扩大的CD8 + T细胞池产生效应子和记忆细胞群，分别提供病毒清除和长期免疫力。在这里，我们证明了3BP2在细胞质微团簇中募集并成核了信号转导复合物，该复合物促进了TCR下游信号通路的MHC：肽非依赖性激活。我们表明，适配器分子3BP2的感应是TCR信号强度的传感器，对于维持CD8 + T细胞的增殖以及调节效应子和记忆的分化至关重要。
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