Toward the Efficient Synthesis of Pseudoionone from Citral in a Continuous-Flow Microreactor,Industrial & Engineering Chemistry Research

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Toward the Efficient Synthesis of Pseudoionone from Citral in a Continuous-Flow Microreactor
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2018-08-13 , DOI: 10.1021/acs.iecr.8b02367
Feng Zhou _{1,

2} , Hongchen Liu _{1,

2} , Zhenghui Wen ₁ , Boyu Zhang ₁ , Guangwen Chen ₁

Affiliation

Pseudoionone (PI) is a well-known and widely used precursor for ionones, which have been substantially applied in flavor, fragrance and pharmaceutical industry. The phase behavior in respect to the synthesis of PI was investigated through the combination of simulation and experiment to better understand the reaction process. A continuous-flow microreactor for efficient synthesis of PI was introduced. Various conditions (temperature, molar ratio of acetone to citral, citral concentration, NaOH concentration, residence time, and volume ratio of ethanol to water) were investigated to improve the synthesis process of PI. The condensation reaction preformed in the tubular and packed-bed microreactor under continuous-flow conditions was compared. Using a continuous-flow microreactor, PI could be efficiently synthesized from citral and a high PI yield of 93.8% could be achieved under the optimized conditions. Furthermore, a simplified kinetic model was developed to provide guidance for the synthesis of PI.

中文翻译：

在连续流微反应器中从柠檬醛高效合成假紫罗酮

假紫罗兰酮（PI）是众所周知的且广泛使用的紫罗兰酮前体，已广泛应用于香料，香料和制药行业。通过模拟和实验相结合的方式研究了有关PI合成的相行为，以更好地了解反应过程。介绍了一种用于高效合成PI的连续流微反应器。研究了各种条件（温度，丙酮与柠檬酸的摩尔比，柠檬酸浓度，NaOH浓度，停留时间以及乙醇与水的体积比）以改善PI的合成过程。比较了在连续流动条件下在管状和填充床微反应器中进行的缩合反应。使用连续流微反应器，从柠檬醛中可以高效合成PI，在最佳条件下可达到93.8％的高PI收率。此外，开发了简化的动力学模型以为PI的合成提供指导。

更新日期：2018-08-14

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