使用松花粉的大分子微囊化：天然材料的负载优化和控释,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

使用松花粉的大分子微囊化：天然材料的负载优化和控释
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-07-26 00:00:00 , DOI: 10.1021/acsami.8b09952
Arun K. Prabhakar _{1,

2} , Michael G. Potroz _{1,

2} , Ee-Lin Tan _{1,

2} , Haram Jung _{1,

2} , Jae Hyeon Park _{1,

2} , Nam-Joon Cho _{1,

2,

3}

Affiliation

松花粉提供了具有双中空气囊的全天然多腔结构，可提供足够的载货量来进行复合物装载。然而，由于存在脂类化合物的天然防水薄层，花粉显示出降低的渗透性。在本文中，我们探索了松花粉中化合物装载量的潜力以及开发用于靶向递送至肠道的全天然制剂的潜力。显示去除表面粘附的脂质化合物可改善表面润湿性，在花粉外壳中暴露出纳米通道结构并增强整个花粉结构中的吸水率。上样参数的优化实现了在外部花粉壳六边形结构内有效的化合物上样，其中牛血清白蛋白（BSA）作为代表蛋白。基于装满BSA的脱脂松花粉的压片技术，开发了全天然的口服给药配方，其中掺入了黄原胶作为天然粘合剂，或离子交联的藻酸钠作为肠溶衣。展望未来，松散的花粉容量大，易于装料，具有竞争力的成本，丰富的可用性以及广泛的历史用途（作为食品和药品）使松花粉成为具有广泛应用潜力的有吸引力的微囊化剂。

"点击查看英文标题和摘要"

Macromolecular Microencapsulation Using Pine Pollen: Loading Optimization and Controlled Release with Natural Materials

Pine pollen offers an all-natural multicavity structure with dual hollow air sacs, providing ample cargo capacity available for compound loading. However, the pollen exhibits reduced permeability because of the presence of a thin natural water-proofing layer of lipidic compounds. Herein, we explore the potential for compound loading within pine pollen and the potential for developing all-natural formulations for targeted delivery to the intestinal tract. Removal of the surface-adhered lipidic compounds is shown to improve surface wetting, expose nanochannel structures in the outer pollen shell and enhance water uptake throughout the whole pollen structure. Optimization of loading parameters enabled effective compound loading within the outer pollen shell sexine structure, with bovine serum albumin (BSA) serving as a representative protein. All-natural oral delivery formulations for targeted intestinal delivery are developed based on tableting of BSA-loaded defatted pine pollen, with the incorporation of xanthan gum as a natural binder, or ionotropically cross-linked sodium alginate as an enteric coating. Looking forward, the large cargo capacity, ease of compound loading, competitive cost, abundant availability, and extensive historical usage as food and medicine make pine pollen an attractive microencapsulant for a wide range of potential applications.

更新日期：2018-07-26

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南