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Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways.
Neuron ( IF 14.7 ) Pub Date : 2018-07-26 , DOI: 10.1016/j.neuron.2018.07.010 Chia-Yu Yeh 1 , Brent Asrican 1 , Jonathan Moss 2 , Luis Jhoan Quintanilla 3 , Ting He 1 , Xia Mao 4 , Frederic Cassé 5 , Elias Gebara 2 , Hechen Bao 1 , Wei Lu 4 , Nicolas Toni 5 , Juan Song 6
Neuron ( IF 14.7 ) Pub Date : 2018-07-26 , DOI: 10.1016/j.neuron.2018.07.010 Chia-Yu Yeh 1 , Brent Asrican 1 , Jonathan Moss 2 , Luis Jhoan Quintanilla 3 , Ting He 1 , Xia Mao 4 , Frederic Cassé 5 , Elias Gebara 2 , Hechen Bao 1 , Wei Lu 4 , Nicolas Toni 5 , Juan Song 6
Affiliation
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Mossy cells (MCs) represent a major population of excitatory neurons in the adult dentate gyrus, a brain region where new neurons are generated from radial neural stem cells (rNSCs) throughout life. Little is known about the role of MCs in regulating rNSCs. Here we demonstrate that MC commissural projections structurally and functionally interact with rNSCs through both the direct glutamatergic MC-rNSC pathway and the indirect GABAergic MC-local interneuron-rNSC pathway. Specifically, moderate MC activation increases rNSC quiescence through the dominant indirect pathway, while high MC activation increases rNSC activation through the dominant direct pathway. In contrast, MC inhibition or ablation leads to a transient increase of rNSC activation, but rNSC depletion only occurs after chronic ablation of MCs. Together, our study identifies MCs as a critical stem cell niche component that dynamically controls adult NSC quiescence and maintenance under various MC activity states through a balance of direct glutamatergic and indirect GABAergic signaling onto rNSCs.
中文翻译：
苔藓细胞通过直接途径和间接途径之间的动态平衡来控制成人神经干细胞的静止和维持。
苔藓细胞（MCs）代表成年人齿状回中的主要兴奋性神经元，大脑是整个区域中从radial神经干细胞（rNSC）产生新神经元的大脑区域。关于MC在调节rNSC中的作用知之甚少。在这里，我们证明了MC连合投射在结构上和功能上都通过直接谷氨酸能MC-rNSC途径和间接GABA能MC局部interneuron-rNSC途径与rNSC相互作用。具体而言，中等程度的MC激活可通过显性间接途径增加rNSC静止，而高度MC激活可通过显性直接途径增加rNSC激活。相反，MC抑制或消融导致rNSC激活的瞬时增加，但rNSC耗竭仅在MC慢性消融后发生。一起，
更新日期：2018-07-26
中文翻译：
苔藓细胞通过直接途径和间接途径之间的动态平衡来控制成人神经干细胞的静止和维持。
苔藓细胞（MCs）代表成年人齿状回中的主要兴奋性神经元，大脑是整个区域中从radial神经干细胞（rNSC）产生新神经元的大脑区域。关于MC在调节rNSC中的作用知之甚少。在这里，我们证明了MC连合投射在结构上和功能上都通过直接谷氨酸能MC-rNSC途径和间接GABA能MC局部interneuron-rNSC途径与rNSC相互作用。具体而言，中等程度的MC激活可通过显性间接途径增加rNSC静止，而高度MC激活可通过显性直接途径增加rNSC激活。相反，MC抑制或消融导致rNSC激活的瞬时增加，但rNSC耗竭仅在MC慢性消融后发生。一起，
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