Effect of Regioisomerism on the Efficiency of 1-Phenylpyrrole-Type Atropisomeric Amino Alcohol Ligands in Enantioselective Organometallic Reactions,Synlett

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Effect of Regioisomerism on the Efficiency of 1-Phenylpyrrole-Type Atropisomeric Amino Alcohol Ligands in Enantioselective Organometallic Reactions
Synlett ( IF 1.7 ) Pub Date : 2018-07-25 , DOI: 10.1055/s-0037-1610551
Ferenc Faigl ₁ , Béla Mátravölgyi ₁ , Szilvia Deák ₁ , Zsuzsanna Erdélyi ₁ , Tamás Hergert ₁ , Péter Ábrányi-Balogh ₂

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Syntheses of two regioisomeric series of atropisomeric amino alcohols and a comparative study on their application in the enantioselective addition of diethylzinc to benzaldehyde are reported. Systematic modification of the electronic and steric properties of the functional groups resulted in highly efficient catalyst ligands in both series. Quantum-chemical calculations agreed well with the experimental results of this first systematic comparative study on regioisomeric atropisomeric ligands.

中文翻译：

区域异构对 1-苯基吡咯型阻转异构氨基醇配体在对映选择性有机金属反应中效率的影响

报道了两种区域异构系列的阻转异构氨基醇的合成及其在二乙基锌与苯甲醛的对映选择性加成中的应用的比较研究。官能团的电子和空间性质的系统改性导致了两个系列的高效催化剂配体。量子化学计算与第一次对区域异构阻转异构配体的系统比较研究的实验结果非常吻合。

更新日期：2018-07-25

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