(2-(4-Bromophenyl)ethene-1,1,2-triyl)tribenzene with aggregation induced emission for ablation of HeLa cells†,Materials Chemistry Frontiers

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(2-(4-Bromophenyl)ethene-1,1,2-triyl)tribenzene with aggregation induced emission for ablation of HeLa cells†
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2018-07-25 00:00:00 , DOI: 10.1039/c8qm00304a
Jie Yang _{1,

2,

3,

4,

5} , Xiaoqing Gu _{1,

2,

3,

4,

5} , Wanting Su _{1,

2,

3,

4,

5} , Xinyu Hao _{1,

2,

3,

4,

5} , Yujie Shi _{1,

2,

3,

4,

5} , Liyun Zhao _{5,

6,

7,

8} , Dengfeng Zou _{5,

6,

7,

8} , Gaowen Yang _{1,

2,

3,

4,

5} , Qiaoyun Li _{1,

2,

3,

4,

5} , Jianhua Zou _{1,

2,

3,

4,

5}

Affiliation

It is of great importance for a photosensitizer to be soluble in aqueous solutions, while simultaneously remaining highly fluorescent. Towards this goal, (2-(4-bromophenyl)ethene-1,1,2-triyl)tribenzene (denoted as TPE-Br) with aggregation induced emission (AIE) was prepared. 1,2-Distearoyl-sn-glycero-3-phospho-ethanolamine-N-[methoxy(polyethyleneglycol)_-2000] (DSPE-PEG_-2000) coated TPE-Br nanoparticles (NPs) have a strong ability to generate singlet oxygen using singlet oxygen sensor green (SOSG) as a probe and still retain high fluorescence in aqueous solutions. In vitro cytotoxicity assays demonstrate that these NPs are able to kill HeLa cells effectively and the half-maximal inhibitory concentration (IC₅₀) is as low as 12 μg mL⁻¹. Furthermore, in vivo investigation suggests that TPE-Br NPs are able to inhibit the growth of the tumors after irradiation without adverse effects to normal organs, including the heart, liver, spleen, lung and kidney. This indicates the significantly low dark toxicity and excellent biocompatibility of such NPs.

中文翻译：

（2-（4-溴苯基）乙烯-1,1,2-三基）三苯具有聚集诱导的HeLa细胞消融发射†

光敏剂可溶于水溶液，同时保持高荧光性是非常重要的。为了达到这个目标，制备了具有聚集诱导发射（AIE）的（2-（4-溴苯基）乙烯-1,1,2-三基）三苯（表示为TPE-Br）。1,2-二硬脂酰基-sn-甘油-3-磷酸-乙醇胺-N- [甲氧基（聚乙二醇）_-2000 ]（DSPE-PEG _-2000）包被的TPE-Br纳米颗粒（NPs）具有很强的生成单线态氧的能力单线态氧传感器绿色（SOSG）作为探针，并且在水溶液中仍保留高荧光。体外细胞毒性试验表明，这些NP能够有效杀死HeLa细胞，半数抑制浓度（IC ₅₀）低至12μgmL ^-1。此外，体内研究表明，TPE-Br NPs能够抑制辐射后肿瘤的生长，而不会对包括心脏，肝脏，脾脏，肺脏和肾脏在内的正常器官产生不利影响。这表明此类NP的暗毒性极低，且生物相容性极佳。

更新日期：2018-07-25

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