Which wavelength is optimal for transcranial low-level laser stimulation?,Journal of Biophotonics

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Which wavelength is optimal for transcranial low-level laser stimulation?
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2018-10-01 , DOI: 10.1002/jbio.201800173
Pengbo Wang _{1,

2} , Ting Li _{1,

2}

Affiliation

One of the challenges in transcranial low‐level laser therapy (LLLT) is to optimally choose illumination parameters, such as wavelength. However, there is sparse study on the wavelengths comparison especially on human transcranial LLLT. Here, we employed Monte Carlo modeling and visible human phantom to compute the penetrated photon fluence distribution within cerebral cortex. By comparing the fluence distribution, penetration depth and the intensity of laser‐tissue‐interaction within brain among all candidate wavelengths, we found that 660, 810 nm performed much better than 980, 1064 nm with much stronger, deeper and wider photon penetration into cerebral tissue; 660 nm was shown to be the best and slightly better than 810 nm. Our computational finding was in a surprising accordance with previous LLLT‐neurobehavioral studies on mice. This study not only offered quantitative comparison among wavelengths in the effect of LLLT light penetration effectiveness but also anticipated a delightful possibility of online, precise and visible optimization of LLLT illumination parameters.

中文翻译：

哪种波长最适合经颅低水平激光刺激？

经颅低水平激光治疗（LLLT）的挑战之一是优化选择照明参数，例如波长。但是，对波长比较的研究很少，尤其是对人类经颅LLLT的波长比较。在这里，我们采用了蒙特卡洛模型和可见人体模型来计算大脑皮层中穿透的光子通量分布。通过比较所有候选波长之间的注量分布，穿透深度和大脑内激光组织相互作用的强度，我们发现660、810 nm的性能远好于980、1064 nm，光子对大脑的穿透力更强，更深，更宽组织; 660 nm是最好的，略好于810 nm。我们的计算发现与先前对小鼠进行的LLLT神经行为研究惊人地一致。

更新日期：2018-10-01

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