High‐Security Nanocluster for Switching Photodynamic Combining Photothermal and Acid‐Induced Drug Compliance Therapy Guided by Multimodal Active‐Targeting Imaging,Advanced Functional Materials

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High‐Security Nanocluster for Switching Photodynamic Combining Photothermal and Acid‐Induced Drug Compliance Therapy Guided by Multimodal Active‐Targeting Imaging
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-07-23 , DOI: 10.1002/adfm.201803118
Kai Cheng ₁ , Xiao-Quan Yang _{1,

2} , Xiao-Shuai Zhang ₁ , Jun Chen ₃ , Jie An ₁ , Yuan-Yang Song ₁ , Cheng Li ₁ , Yang Xuan ₁ , Ruo-Yun Zhang ₁ , Chun-Hua Yang ₄ , Xian-Lin Song ₂ , Yuan-Di Zhao _{1,

2} , Bo Liu _{1,

2}

Affiliation

High‐security nanoplatform with enhanced therapy compliance is extremely promising for tumor. Herein, using a simple and high‐efficient self‐assembly method, a novel active‐targeting nanocluster probe, namely, Ag₂S/chlorin e6 (Ce6)/DOX@DSPE‐mPEG₂₀₀₀‐folate (ACD‐FA) is synthesized. Experiments indicate that ACD‐FA is capable of specifically labeling tumor and guiding targeting ablation of the tumor via precise positioning from fluorescence and photoacoustic imaging. Importantly, the probe is endowed with a photodynamic “on‐off” effect, that is, Ag₂S could effectively quench the fluorescence of chlorin e6 (89.5%) and inhibit release of ¹O₂ (92.7%), which is conducive to avoid unwanted phototoxicity during transhipment in the body, and only after nanocluster endocytosed by tumor cells could release Ce6 to produce ¹O₂. Moreover, ACD‐FA also achieves excellent acid‐responsive drug release, and exhibits eminent chemo‐photothermal and photodynamic effects upon laser irradiation. Compared with single or two treatment combining modalities, ACD‐FA could provide the best cancer therapeutic effect with a relatively low dose, because it made the most of combined effect from chemo‐photothermal and controlled photodynamic therapy, and significantly improves the drug compliance. Besides, the active‐targeting nanocluster notably reduces nonspecific toxicity of both doxorubicin and chlorin e6. Together, this study demonstrates the potency of a newly designed nanocluster for nonradioactive concomitant therapy with precise tumor‐targeting capability.

中文翻译：

高安全性纳米集群，可在多峰主动靶向成像的指导下，将光热和酸诱导的药物依从性治疗相结合的光动力转换

具有增强治疗依从性的高安全性纳米平台对肿瘤极为有前途。在此，使用一种简单高效的自组装方法，合成了一种新型的主动靶向纳米簇探针，即Ag ₂ S /二氢卟酚e6（Ce6）/ DOX @ DSPE-mPEG ₂₀₀₀叶酸（ACD-FA）。实验表明，ACD-FA能够通过荧光和光声成像的精确定位来特异性标记肿瘤并指导肿瘤的靶向消融。重要的是，该探针具有光动力学“开-关”效果，即Ag ₂ S可以有效淬灭二氢卟酚e6（89.5％）的荧光并抑制¹ O _2的释放。（92.7％），这有助于避免在体内转运过程中产生有害的光毒性，并且只有在被肿瘤细胞内吞的纳米簇之后才能释放Ce6产生¹ O _2。。此外，ACD-FA还实现了出色的酸响应性药物释放，并在激光照射下表现出卓越的化学光热和光动力效应。与单一或两种联合治疗方式相比，ACD-FA可以以相对较低的剂量提供最佳的癌症治疗效果，因为它充分利用了化学光热疗法和可控光动力疗法的综合疗效，并显着提高了药物依从性。此外，靶向活性的纳米簇显着降低了阿霉素和二氢卟酚e6的非特异性毒性。总之，这项研究证明了新型设计的纳米簇在非放射性伴随疗法中具有精确的肿瘤靶向能力。

更新日期：2018-07-23

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