简单的热预处理策略可调节两性离子水凝胶的机械和防污性能,Langmuir

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简单的热预处理策略可调节两性离子水凝胶的机械和防污性能
Langmuir ( IF 3.7 ) Pub Date : 2018-07-23 00:00:00 , DOI: 10.1021/acs.langmuir.8b01755
Huacheng He ₁ , Xuan Xuan ₂ , Cuiyun Zhang ₂ , Yi Song ₂ , Shengfu Chen ₃ , Xiong Gong , Baiping Ren , Jie Zheng , Jiang Wu ₂

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两性离子水凝胶因其高水含量，三维网络结构和防污性能而成为有前途的生物材料。但是，两性离子水凝胶的机械性能如何影响其防污性能仍不清楚。在这项工作中，我们提出了一种简单的热预处理方法来制备具有各种机械性能的聚（磺基甜菜碱甲基丙烯酸甲酯）（pSBMA）水凝胶，可以通过热预处理时间和交联剂密度轻松对其进行调节，并使其机械性能相互关联。具有防污性能。与未处理的水凝胶相比，所得的经热处理的pSBMA水凝胶显示出显着增强的机械性能，且压缩模数和弹性模数可调。ELISA研究和短期细胞粘附测定的结合还证实了pSBMA水凝胶具有出色的防污性能，可以抵抗蛋白质的吸附和细胞粘附。进一步的分析表明，pSBMA水凝胶的弹性模量与蛋白质吸附之间存在线性反相关关系，即，具有较高弹性模量的水凝胶显示出较低的蛋白质吸附（较好的防污性能）。这项工作不仅为制造pSBMA水凝胶提供了一种简单的热预处理策略，而且还证明了pSBMA水凝胶的多功能特性，具有实现某些生物医学应用的巨大潜力。进一步的分析表明，pSBMA水凝胶的弹性模量与蛋白质吸附之间存在线性反相关关系，即，具有较高弹性模量的水凝胶显示出较低的蛋白质吸附（较好的防污性能）。这项工作不仅为制造pSBMA水凝胶提供了一种简单的热预处理策略，而且还证明了pSBMA水凝胶的多功能特性，具有实现某些生物医学应用的巨大潜力。进一步的分析表明，pSBMA水凝胶的弹性模量与蛋白质吸附之间存在线性反相关关系，即，具有较高弹性模量的水凝胶显示出较低的蛋白质吸附（较好的防污性能）。这项工作不仅为制造pSBMA水凝胶提供了一种简单的热预处理策略，而且还证明了pSBMA水凝胶的多功能特性，具有实现某些生物医学应用的巨大潜力。

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Simple Thermal Pretreatment Strategy to Tune Mechanical and Antifouling Properties of Zwitterionic Hydrogels

Zwitterionic hydrogels are promising biomaterials because of their high water content, three-dimensional network structure, and antifouling property. However, it still remains unclear about how mechanical properties of zwitterionic hydrogels affect their antifouling property. In this work, we propose a simple, thermal-pretreatment method to fabricate poly(sulfobetaine methacrylate) (pSBMA) hydrogels with varied mechanical properties that can be readily tuned by thermal pretreatment time and cross-linker density, as well as to correlate their mechanical property with antifouling property. The resulting thermal-treated pSBMA hydrogels show significantly enhanced mechanical properties with tunable compressive modulus and elastic modulus as compared to the untreated hydrogels. A combination of ELISA investigations and short-term cell adhesion assays also confirm that pSBMA hydrogels exhibit superior antifouling properties to resist protein adsorption and cell adhesion. Further analysis shows a linear inversion correlation between elastic modulus and protein adsorption of pSBMA hydrogels, i.e., the hydrogel with the higher elastic modulus exhibits the lower protein adsorption (the better antifouling property). This work not only provides a simple thermal-pretreatment strategy for fabricating pSBMA hydrogels, but also demonstrates multifunctional properties of the pSBMA hydrogels, which possess a great potential to fulfill some biomedical applications.

更新日期：2018-07-23

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