Palladium-Catalyzed Arylation of Aromatic Amides Directed by a [4-Chloro-2-(1H-pyrazol-1-yl)phenyl]amine Auxiliary,Synlett

当前位置： X-MOL 学术 › Synlett › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Palladium-Catalyzed Arylation of Aromatic Amides Directed by a [4-Chloro-2-(1H-pyrazol-1-yl)phenyl]amine Auxiliary
Synlett ( IF 1.7 ) Pub Date : 2018-07-20 , DOI: 10.1055/s-0037-1609558
Ya-Fei Ji ₁ , Ya-Hua Hu ₁ , Zhi Xu ₁ , Ling-Yan Shao ₁

Affiliation

A palladium-catalyzed ortho-arylation of aromatic amides directed by [4-chloro-2-(1H-pyrazol-1-yl)phenyl]amine as a bidentate auxiliary has been established. The reaction is characterized by normal working conditions, a broad substrate scope, and a wide functional-group tolerance. In particular, the protocol is compatible with highly sterically demanding ortho-substituted anilides and aryl iodide partners, with good yields.

中文翻译：

由[4-氯-2-(1H-吡唑-1-基)苯基]胺助剂指导的芳族酰胺的钯催化芳基化

已经建立了钯催化的芳族酰胺的邻芳基化，由 [4-氯-2-(1H-吡唑-1-基)苯基]胺作为双齿助剂。该反应的特点是正常的工作条件、广泛的底物范围和广泛的官能团耐受性。特别是，该协议与高空间要求的邻位取代苯胺和芳基碘化物相兼容，并具有良好的产量。

更新日期：2018-07-20

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南