Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(iii)-complexes supported by a common N-heterocyclic carbene†,New Journal of Chemistry

当前位置： X-MOL 学术 › New J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(iii)-complexes supported by a common N-heterocyclic carbene†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-07-17 00:00:00 , DOI: 10.1039/c8nj02008f
Lalmohan Jhulki _{1,

2,

3,

4} , Parul Dutta _{4,

5,

6} , Manas Kumar Santra _{4,

5,

6} , Marlon H. Cardoso _{7,

8,

9,

10,

11} , Karen G. N. Oshiro _{7,

8,

9,

10,

11} , Octávio L. Franco _{7,

8,

9,

10,

11} , Valerio Bertolasi _{12,

13,

14,

15} , Anvarhusein A. Isab _{16,

17,

18,

19} , Christopher W. Bielawski _{20,

21,

22,

23,

24} , Joydev Dinda _{4,

16,

25,

26}

Affiliation

School of Applied Science
Haldia Institute of Technology
Haldia 721657
India
National Centre for Cell Science
Pune 411007
Programa de Pós-Graduação em Patologia Molecular
Faculdade de Medicina
Universidade de Brasília
Brasília-DF
Brazil
Dipartimento di Scienze Chimiche e Farmaceutiche
Centro di Strutturistica Diffrattometrica
Universita' di Ferrara
Italy
Department of Chemistry
King Fahd University of Petroleum and Minerals
Dhahran 31261
Saudi Arabia
Center for Multidimensional Carbon Materials (CMCM)
Institute for Basic Science (IBS)
Ulsan 44919
Republic of Korea
Department of Chemistry and Department of Energy Engineering
Utkal University
Bhubaneswar 751004

The synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(I) (2), Au(I) (3) and Au(III) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2–4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(I) and Ag(I) complexes were more potent than their Au(III) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis.

中文翻译：

一系列由常见的N杂环卡宾支撑的Ag（i）-，Au（i）-和Au（iii）配合物显示的合成和细胞毒性特征†

突出了由1-甲基-2-（苯基）咪唑并[1,5 - a ]吡啶-2-亚基（1）负载的一系列贵金属配合物的合成，结构和抗癌研究。Ag（I）（2），Au（I）（3）和Au（III）（4）配合物是使用标准方法制备的，并通过一系列技术进行了表征，包括NMR光谱，X射线晶体学和元素分析。在体外细胞毒性活性显示由2-4针对人结肠腺癌（HCT116），肺癌（A549）和乳腺癌（MCF7）细胞系进行了研究。一系列测定表明，所有复合物在上述细胞系中均表现出显着的生长抑制作用。检查所收集的数据表明，Au（I）和Ag（I）配合物比其Au（III）同系物更有效，这一趋势与以BCL-2作为模型的分子对接研究相符。该蛋白通过细胞凋亡调节细胞死亡。

更新日期：2018-07-17

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南