A general method for asymmetric synthesis of alkylated homoallylic amines was developed via a one-pot three-component reaction of easily available N-phosphonyl amides, aliphatic aldehydes, and allylic Grignard reagents. As anticipated the reaction proceeds through six-membered chelation controlled mechanism, allowing 1,2-nucleophilic addition to directly give chiral homoallylic amines with high yields and excellent diastereoselectivity.

中文翻译：

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通过格氏试剂与脂肪族N-膦酰基半缩醛的1,2-加成反应合成不对称胺

通过容易获得的N-膦酰基酰胺，脂肪族醛和烯丙基格利雅试剂的一锅三组分反应，开发了一种不对称合成烷基化均烯丙基胺的通用方法。如所预期的，反应通过六元螯合控制机制进行，允许1，2-亲核加成以高收率和优异的非对映选择性直接得到手性均烯丙基胺。