Background

Regular consumption of opioids exposes individuals to several side effects. One of these is a loss of libido, which has a negative impact on quality of life. We used a cross-sectional community-based survey of people who inject opioids to study factors associated with loss of libido, and more particularly the impact of the type of opioid injected.

Methods

This secondary study was conducted throughout France in 2015 and involved 514 people who inject opioids. Self-reported sociodemographic characteristics, drug consumption, injection-related data and loss of libido were collected using a brief questionnaire administered either through face-to-face interviews or online. Two different models were used to identify factors associated with loss of libido: simple logistic regression and a two-step Heckman model.

Results

Forty-three percent of the participants reported a loss of libido. The first model showed that filling in the questionnaire online (OR[95%CI] = 2.55[1.64;3.96]; p < 0.001), reporting that morphine sulfate (OR[95%CI] = 2.67[1.56;4.58]; p < 0.001) or methadone (OR[95%CI] = 2.50[1.13;5.56]; p = 0.030) was the opioid they injected most (versus buprenorphine), and reporting benzodiazepine use (OR[95%CI] = 1.62[1.07;2.44]; p = 0.033) were factors strongly associated with loss of libido. In the two-step, Heckman model which corrected for selection bias, along with these factors, reporting heroin as the opioid injected most was also strongly associated.

Conclusion

Our findings showed that full-opioid agonists could have a negative impact on libido when injected regularly. Libido can improve quality of life and should be routinely discussed through counseling in prevention services with people who inject drugs.

中文翻译：

---

与注射阿片类药物的人的性欲减退有关的因素：法国一项基于社区的调查结果

背景

经常食用阿片类药物会使个人面临多种副作用。其中之一是性欲下降，这对生活质量产生负面影响。我们对注射阿片类药物的人进行了一项基于社区的横断面调查，以研究与性欲减退有关的因素，尤其是注射阿片类药物类型的影响。

方法

这项次级研究于2015年在法国各地进行，涉及514名注射阿片类药物的人。自我报告的社会人口统计学特征，药物消耗，与注射有关的数据和性欲减退均采用通过面对面访谈或在线方式进行的简短问卷调查来收集。使用两种不同的模型来识别与性欲丧失相关的因素：简单逻辑回归和两步Heckman模型。

结果

43％的参与者报告性欲下降。第一个模型显示在线填写问卷（OR [95％CI] = 2.55 [1.64; 3.96]； p <0.001），报告说硫酸吗啡（OR [95％CI] = 2.67 [1.56; 4.58]； p <0.001）或美沙酮（OR [95％CI] = 2.50 [1.13; 5.56]； p = 0.030）是他们注射最多的阿片类药物（对丁丙诺啡），并报告使用苯二氮卓类药物（OR [95％CI] = 1.62 [1.07] ; 2.44]; p = 0.033）是与性欲丧失密切相关的因素。在两步修正了选择偏倚的Heckman模型以及这些因素的影响下，报告海洛因是注射的阿片类药物最多的国家也紧密相关。

结论

我们的研究结果表明，定期注射全阿片类激动剂可能会对性欲产生负面影响。力比多可以改善生活质量，应该在与注射毒品者进行预防服务的咨询中定期进行讨论。