NIR Fluorescent AzaBODIPY‐Based Probe for the Specific Detection of L–Lysine,ChemistrySelect

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NIR Fluorescent AzaBODIPY‐Based Probe for the Specific Detection of L–Lysine
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-07-09 , DOI: 10.1002/slct.201701809
Xin‐Dong Jiang _{1,

2} , Shuai Yue ₁ , Lei Jia ₁ , Shuang Li ₁ , Congling Li ₁ , Qian Li ₃ , Linjiu Xiao ₁

Affiliation

With 1‐(5‐chloro‐thiophen‐2‐yl)‐ethanone as the starting material, 3,5‐dichloro‐azaBODIPY 2 was successfully prepared. AzaBODIPY can be modified by nucleophilic monosubstitution with N‐nucleophile at room temperature. Since the previous work on specifically detecting L‐lysine (Lys) is scarce, dichloro‐azaBODIPY 2 is valuable as a probe for detecting Lys. Probe 2 was found to be selective and sensitive to Lys. Moreover, probe 2 can be used to detect Lys in PC3 cells, indicating its potential application for studying the effect of Lys in biological systems.

中文翻译：

基于NIR荧光AzaBODIPY的探针，用于L-赖氨酸的特异性检测

以1-（5-氯噻吩-2-基）乙酮为原料，成功制备了3,5-二氯氮杂BODIPY 2。AzaBODIPY可以在室温下通过亲核单取代N-亲核试剂进行修饰。由于以前专门检测L-赖氨酸（Lys）的工作很少，因此二氯azaBODIPY 2作为检测Lys的探针非常有价值。发现探针2对Lys具有选择性和敏感性。此外，探针2可用于检测PC3细胞中的Lys，表明其潜在用途可用于研究Lys在生物系统中的作用。

更新日期：2018-07-09

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