Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles,Journal of Materials Chemistry B

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Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-07-06 00:00:00 , DOI: 10.1039/c8tb00948a
Padmanaban Sivakumar _{1,

2,

3,

4} , Minjong Lee _{4,

5,

6,

7} , Yoon-Seok Kim _{1,

2,

3,

4} , Min Suk Shim _{1,

2,

3,

4}

Affiliation

ZnO nanoparticles (ZnO NPs) have gained more attention in recent years due to their ability to induce the generation of reactive oxygen species (ROS) under light irradiation. Photo-triggered ROS generation by ZnO NPs and the resulting phototoxicity in cells have found use in antibacterial and anticancer applications. This review highlights recent advances in the development of ZnO NPs and hybrid-type functionalized ZnO NPs for photo-triggered antibacterial and anticancer activities. In addition, various chemical modifications including metal doping, metal hybridization, modification with polymers, and sensitization by organic photosensitizers have been further introduced to enhance the photocatalytic efficiency and ROS generation capability of ZnO NPs. The enhanced ROS generation efficiency of modified ZnO NPs consequently increases their antibacterial and anticancer activities. Additionally, we offer some insights into the design and engineering of next-generation ZnO NPs for more effective antibacterial and anticancer applications.

中文翻译：

氧化锌纳米粒子的光触发抗菌和抗癌活性

近年来，由于ZnO纳米颗粒（ZnO NPs）能够在光照射下诱导活性氧（ROS）的产生，因此受到了越来越多的关注。ZnO NPs通过光触发产生ROS，并在细胞中产生光毒性，已用于抗菌和抗癌应用。这篇综述重点介绍了用于光触发的抗菌和抗癌活性的ZnO NP和杂合型功能化ZnO NP的开发方面的最新进展。此外，还引入了各种化学修饰，包括金属掺杂，金属杂化，聚合物修饰以及有机光敏剂的敏化作用，以增强ZnO NP的光催化效率和ROS产生能力。修饰的ZnO NP的ROS生成效率提高，因此增加了其抗菌和抗癌活性。此外，我们为更有效的抗菌和抗癌应用提供了下一代ZnO NP的设计和工程方面的一些见识。

更新日期：2018-07-06

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