A Concise Review on the Synthesis and Reactions of Pyrazolopyrazine Heterocycles,Journal of Heterocyclic Chemistry

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A Concise Review on the Synthesis and Reactions of Pyrazolopyrazine Heterocycles
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2018-07-06 , DOI: 10.1002/jhet.3225
Mokhtar A. Abd ul-Malik _{1,

2} , Remon M. Zaki ₁ , Adel M. Kamal El-Dean ₁ , Shaban M. Radwan ₁

Affiliation

The pyrazolopyrazine ring system is a very interesting class of heterocyclic compounds that were considered as important scaffolds of many efficacious biologically active agents that show anticancer with low toxicity, antioxidant, anticonvulsant, antiparasitic, anti‐inflammatory, antiviral, antibacterial, antifungal, and analgesic activities. This review throws light on the detailed synthetic approaches for the synthesis and reactions of pyrazolopyrazine moiety. This follow up may encourage the chemists to generate new routes possessing pyrazolopyrazine nucleus with high efficacy.

中文翻译：

吡唑并吡嗪杂环的合成与反应简述

吡唑并吡嗪环系统是一类非常有趣的杂环化合物，被认为是许多有效的生物活性剂的重要支架，这些活性剂具有低毒，抗氧化剂，抗惊厥，抗寄生虫，抗炎，抗病毒，抗菌，抗真菌和镇痛活性。这篇综述阐明了吡唑并吡嗪部分的合成和反应的详细合成方法。后续研究可能会鼓励化学家们开发出具有吡唑并吡嗪核的高效新途径。

更新日期：2018-07-06

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