Exploiting the Catalytic Diversity of Short‐Chain Dehydrogenases/Reductases: Versatile Enzymes from Plants with Extended Imine Substrate Scope,ChemBioChem

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Exploiting the Catalytic Diversity of Short‐Chain Dehydrogenases/Reductases: Versatile Enzymes from Plants with Extended Imine Substrate Scope
ChemBioChem ( IF 2.6 ) Pub Date : 2018-08-07 , DOI: 10.1002/cbic.201800291
Sebastian Roth ₁ , Matthew B. Kilgore ₂ , Toni M. Kutchan ₂ , Michael Müller ₁

Affiliation

One enzyme, three activities: The plant SDR noroxomaritidine reductase (NR) serves as an enone reductase in alkaloid biosynthesis. Here, we show that NR accepts different imine compounds and features a keto reductase activity. With NR as a template, we have identified a novel imine‐reducing SDR.