Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide–Dendron Hybrids,Biomacromolecules

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Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide–Dendron Hybrids
Biomacromolecules ( IF 5.5 ) Pub Date : 2015-12-23 00:00:00 , DOI: 10.1021/acs.biomac.5b01452
Jeannette E Marine ₁ , Shuang Song ₁ , Xiaoli Liang ₁ , Jonathan G Rudick ₁

Affiliation

Dendronized helix bundle assemblies combine the sequence diversity and folding properties of proteins with the tailored physical properties of dendrimers. Assembly of peptide–dendron hybrids into α-helical bundles encapsulates the helix bundle motif in a dendritic sheath that will allow the functional, protein-like domain to be transplanted to nonbiological environments. A bioorthogonal graft-to synthetic strategy for preparing helix bundle-forming peptide–dendron hybrids is described herein for hybrids 1a, 1b, and 2. Titration experiments monitored by circular dichroism spectroscopy support our self-assembly model for how the peptide–dendron hybrids self-assemble into α-helical bundles with the dendrons on outside of the bundle.

中文翻译：

成束α-螺旋肽-Dendron 杂化物的合成和自组装

树枝状螺旋束组件将蛋白质的序列多样性和折叠特性与树枝状聚合物的定制物理特性结合起来。将肽-树突杂合体组装成α-螺旋束，将螺旋束基序封装在树突鞘中，这将允许功能性蛋白质样结构域移植到非生物环境中。本文描述了用于制备螺旋束形成肽-树突杂合体的生物正交移植合成策略，用于杂合体1a、1b和2。圆二色光谱监测的滴定实验支持我们的自组装模型，即肽-树突杂化物如何自组装成α螺旋束，其中树突位于束的外部。

更新日期：2015-12-23

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