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Continuous flow biocatalysis
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-06-20 00:00:00 , DOI: 10.1039/c7cs00906b Joshua Britton 1 , Sudipta Majumdar , Gregory A Weiss
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-06-20 00:00:00 , DOI: 10.1039/c7cs00906b Joshua Britton 1 , Sudipta Majumdar , Gregory A Weiss
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The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals, and materials has grown tremendously over the past ten years. This revolution in chemical manufacturing has resulted from innovations in both new methodology and technology. This field, however, has been predominantly focused on synthetic organic chemistry, and the use of biocatalysts in continuous flow systems is only now becoming popular. Although immobilized enzymes and whole cells in batch systems are common, their continuous flow counterparts have grown rapidly over the past two years. With continuous flow systems offering improved mixing, mass transfer, thermal control, pressurized processing, decreased variation, automation, process analytical technology, and in-line purification, the combination of biocatalysis and flow chemistry opens powerful new process windows. This Review explores continuous flow biocatalysts with emphasis on new technology, enzymes, whole cells, co-factor recycling, and immobilization methods for the synthesis of pharmaceuticals, value-added chemicals, and materials.
中文翻译：
连续流生物催化
活性药物成分、增值化学品和材料的连续流动合成在过去十年中得到了巨大的发展。化学制造领域的这场革命源于新方法和技术的创新。然而，该领域主要集中在合成有机化学，并且在连续流动系统中使用生物催化剂现在才开始流行。尽管批量系统中的固定化酶和全细胞很常见，但它们的连续流对应物在过去两年中增长迅速。连续流动系统提供改进的混合、传质、热控制、加压处理、减少变化、自动化、过程分析技术和在线纯化，生物催化和流动化学的结合打开了强大的新工艺窗口。本综述探讨了连续流生物催化剂，重点关注新技术、酶、全细胞、辅因子回收以及用于合成药物、增值化学品和材料的固定化方法。
更新日期：2018-06-20
中文翻译：
连续流生物催化
活性药物成分、增值化学品和材料的连续流动合成在过去十年中得到了巨大的发展。化学制造领域的这场革命源于新方法和技术的创新。然而，该领域主要集中在合成有机化学，并且在连续流动系统中使用生物催化剂现在才开始流行。尽管批量系统中的固定化酶和全细胞很常见，但它们的连续流对应物在过去两年中增长迅速。连续流动系统提供改进的混合、传质、热控制、加压处理、减少变化、自动化、过程分析技术和在线纯化，生物催化和流动化学的结合打开了强大的新工艺窗口。本综述探讨了连续流生物催化剂，重点关注新技术、酶、全细胞、辅因子回收以及用于合成药物、增值化学品和材料的固定化方法。
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