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Synthesis of 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines using Pictet-Spengler and Bischler-Napieralski cyclisation methods
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-06-18 , DOI: 10.1016/j.tetlet.2018.06.041
Robert D.M. Davies , Jennifer H. Pink , James S. Scott , Andrew Bailey

In the following communication we report routes for the synthesis of a set of 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines. Pictet-Spengler and Bischler-Napieralski methodologies were employed on the relevant indazole precursors and the merits of the two cyclisation reactions for preparing these structures were assessed.



中文翻译:

利用Pictet-Spengler和Bischler-Napieralski环化方法合成8-取代的6-苯基-6,7,8,9-四氢-3 H-吡唑并[4,3- f ]异喹啉

在下面的通讯中,我们报告了一组8-取代的6-苯基-6,7,8,9-四氢-3 H-吡唑并[4,3- f ]异喹啉的合成路线。在相关的吲唑前体上使用了Pictet-Spengler和Bischler-Napieralski方法,并评估了制备这些结构的两个环化反应的优缺点。

更新日期:2018-06-18
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