RGG/RG motifs are RNA binding segments found in many proteins that can partition into membraneless organelles. They occur in the context of low-complexity disordered regions and often in multiple copies. Although short RGG/RG-containing regions can sometimes form high-affinity interactions with RNA structures, multiple RGG/RG repeats are generally required for high-affinity binding, suggestive of the dynamic, multivalent interactions that are thought to underlie phase separation in formation of cellular membraneless organelles. Arginine can interact with nucleotide bases via hydrogen bonding and π-stacking; thus, nucleotide conformers that provide access to the bases provide enhanced opportunities for RGG interactions. Methylation of RGG/RG regions, which is accomplished by protein arginine methyltransferase enzymes, occurs to different degrees in different cell types and may regulate the behavior of proteins containing these regions.

RGG / RG基序是在许多蛋白质中发现的RNA结合片段，可以分割成无膜细胞器。它们出现在低复杂度的无序区域中，并且通常是多个副本。尽管短的含RGG / RG的区域有时可以与RNA结构形成高亲和力相互作用，但高亲和力结合通常需要多个RGG / RG重复序列，这提示了动态的多价相互作用被认为是形成Hg / RG时相分离的基础。细胞无膜细胞器。精氨酸可与核苷酸碱基的互动通过氢键和π堆积；因此，提供接近碱基的核苷酸构象异构体为RGG相互作用提供了更多的机会。RGG / RG区的甲基化是通过蛋白质精氨酸甲基转移酶完成的，在不同的细胞类型中以不同的程度发生，并可能调节包含这些区域的蛋白质的行为。