Nanocrystalline Cellulose Improves the Biocompatibility and Reduces the Wear Debris of Ultrahigh Molecular Weight Polyethylene via Weak Binding,ACS Nano

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Nanocrystalline Cellulose Improves the Biocompatibility and Reduces the Wear Debris of Ultrahigh Molecular Weight Polyethylene via Weak Binding
ACS Nano ( IF 15.8 ) Pub Date : 2015-12-22 00:00:00 , DOI: 10.1021/acsnano.5b04393
Shiwen Wang _{1,

2} , Qiang Feng ₁ , Jiashu Sun ₁ , Feng Gao ₁ , Wei Fan ₁ , Zhong Zhang ₁ , Xiaohong Li ₂ , Xingyu Jiang ₁

Affiliation

The doping of biocompatible nanomaterials into ultrahigh molecular weight polyethylene (UHMWPE) to improve the biocompatibility and reduce the wear debris is of great significance to prolonging implantation time of UHMWPE as the bearing material for artificial joints. This study shows that UHMWPE can form a composite with nanocrystalline cellulose (NCC, a hydrophilic nanosized material with a high aspect ratio) by ball-milling and hot-pressing. Compared to pure UHMWPE, the NCC/UHMWPE composite exhibits improved tribological characteristics with reduced generation of wear debris. The underlying mechanism is related to the weak binding between hydrophilic NCC and hydrophobic UHMWPE. The hydrophilic, rigid NCC particles tend to detach from the UHMWPE surface during friction, which could move with the rubbing surface, serve as a thin lubricant layer, and protect the UHMWPE substrate from abrasion. The biological safety of the NCC/UHMWPE composite, as tested by MC3T3-E1 preosteoblast cells and macrophage RAW264.7 cells, is high, with significantly lower inflammatory responses/cytotoxicity than pure UHMWPE. The NCC/UHMWPE composite therefore could be a promising alternative to the current UHMWPE for bearing applications.

中文翻译：

纳米晶纤维素通过弱结合提高了生物相容性并减少了超高分子量聚乙烯的磨损碎屑

将生物相容性纳米材料掺入超高分子量聚乙烯（UHMWPE）中以提高生物相容性并减少磨损碎屑对于延长UHMWPE作为人工关节轴承材料的植入时间具有重要意义。这项研究表明，UHMWPE可以通过球磨和热压与纳米晶纤维素（NCC，一种具有高长径比的亲水性纳米材料）形成复合材料。与纯UHMWPE相比，NCC / UHMWPE复合材料具有改善的摩擦学特性，并减少了磨损碎屑的产生。潜在的机制与亲水性NCC和疏水性UHMWPE之间的弱结合有关。亲水的，刚性的NCC颗粒在摩擦过程中易于从UHMWPE表面分离，并可能与摩擦表面一起移动，用作薄的润滑剂层，并保护UHMWPE基材不受磨损。通过MC3T3-E1前成骨细胞和巨噬细胞RAW264.7细胞测试，NCC / UHMWPE复合材料的生物安全性很高，其炎症反应/细胞毒性明显低于纯UHMWPE。因此，NCC / UHMWPE复合材料可以成为目前用于轴承应用的UHMWPE的有希望的替代品。

更新日期：2015-12-22

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