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Cyclopeptides from the Sponge Stylissa flabelliformis
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00121
Oh-Seok Kwon 1 , Chang-Kwon Kim 1 , Woong Sub Byun 1 , Joonseok Oh 2, 3 , Yeon-Ju Lee 4 , Hyi-Seung Lee 4 , Chung J. Sim 5 , Dong-Chan Oh 1 , Sang Kook Lee 1 , Ki-Bong Oh 6 , Jongheon Shin 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00121
Oh-Seok Kwon 1 , Chang-Kwon Kim 1 , Woong Sub Byun 1 , Joonseok Oh 2, 3 , Yeon-Ju Lee 4 , Hyi-Seung Lee 4 , Chung J. Sim 5 , Dong-Chan Oh 1 , Sang Kook Lee 1 , Ki-Bong Oh 6 , Jongheon Shin 1
Affiliation
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Three new cyclopeptides, phakellistatins 20–22 (1–3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity.
中文翻译：
海绵铁笔的环肽
三个新的环肽，phakellistatins 20-22（1 - 3），以及10个已知的相同的结构类的环肽是从热带的海绵中分离Stylissa flabelliformis。通过化学和光谱学方法的组合，确定新化合物的结构为环七肽（1）和两个与phakellistatins有关的差示环十肽（2和3）的差向异构体混合物。评估了环肽对多种癌细胞的体外细胞毒性，化合物2和3表现出显着的活性。
更新日期：2018-06-12
中文翻译：
海绵铁笔的环肽
三个新的环肽，phakellistatins 20-22（1 - 3），以及10个已知的相同的结构类的环肽是从热带的海绵中分离Stylissa flabelliformis。通过化学和光谱学方法的组合，确定新化合物的结构为环七肽（1）和两个与phakellistatins有关的差示环十肽（2和3）的差向异构体混合物。评估了环肽对多种癌细胞的体外细胞毒性，化合物2和3表现出显着的活性。
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