(+)- and (−)-Mangelonoids A and B, two pairs of novel macrocyclic diterpenoid enantiomers featuring an unprecedented bicyclo[9.3.1]pentadecane core and a rare bridgehead double bond, were isolated from Croton mangelong. Their structures were unambiguously established using spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. A plausible biosynthesis pathway for these compounds was proposed. (−)-Mangelonoid A exhibited NF-κB inhibition with an IC₅₀ value of 7.27 ± 1.30 μM.

中文翻译：

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Mangelonoids A和B，从大环二萜对映异构体的两对巴豆mangelong

从克罗顿·曼格隆中分离出（+）-和（-）-类胡萝卜素A和B，这两个对是具有空前的双环[9.3.1]十五烷核心和罕见的桥头双键的新型大环二萜类对映体。使用光谱数据，X射线晶体学和电子圆二色性分析法明确地确定了它们的结构。提出了这些化合物的合理的生物合成途径。（-）-类人猿A表现出NF-κB抑制作用，IC ₅₀值为7.27± 1.30μM 。