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Type 2 Myocardial Infarction—Diagnosis, Prognosis, and Treatment
JAMA ( IF 63.1 ) Pub Date : 2018-08-07 , DOI: 10.1001/jama.2018.7125
Cian P. McCarthy 1 , Muthiah Vaduganathan 2 , James L. Januzzi 3, 4
Affiliation  

Over the past 3 decades, mortality rates for acute myocardial infarction (MI) have declined significantly in large part due to improved evidence-based revascularization techniques, medical therapies, and systems of care. Yet, patients with acute MI represent a diverse group with varying causes for their infarction. Recognizing this, in 2007, the Task Force for the Redefinition of MI created the Universal Definition of MI consensus document, which introduced 5 subtypes of MI (Table).1 One common subtype, type 2 MI, is defined as an MI driven by a myocardial oxygen supply and demand mismatch in the absence of coronary thrombosis. Despite the introduction of type 2 MI over a decade ago, no guidelines or consensus documents are available to aid physicians in clinical management, and limited prospective, high-quality evidence has been generated thus far in this cohort. To date, limited nationally representative data are available estimating the relative incidence of type 2 MI in the United States. Currently, only 1 study listed on ClinicalTrials.gov is actively enrolling patients with type 2 MI (NCT03338504).

中文翻译:

2 型心肌梗死——诊断、预后和治疗

在过去的 3 年里,急性心肌梗死 (MI) 的死亡率在很大程度上由于循证血运重建技术、药物治疗和护理系统的改进而显着下降。然而,急性 MI 患者代表了一个不同的群体,他们的梗塞原因各不相同。认识到这一点,重新定义 MI 的工作组于 2007 年创建了通用定义 MI 共识文件,其中介绍了 MI 的 5 种亚型(表)。 1 一种常见的亚型,即类型 2 MI,被定义为由在没有冠状动脉血栓形成的情况下,心肌氧供需不匹配。尽管十多年前引入了 2 型 MI,但没有指南或共识文件可用于帮助医生进行临床管理,而且前瞻性、迄今为止,该队列已经产生了高质量的证据。迄今为止,可用于估计美国 2 型心梗的相对发病率的全国代表性数据有限。目前,ClinicalTrials.gov 上列出的只有 1 项研究正在积极招募 2 型 MI 患者 (NCT03338504)。
更新日期:2018-08-07
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