Multimodal 19F NMR Dopamine Detection and Imaging with a Nanoparticle‐Based Displacement Assay,Chemistry - A European Journal

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Multimodal 19F NMR Dopamine Detection and Imaging with a Nanoparticle‐Based Displacement Assay
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-07-25 , DOI: 10.1002/chem.201802482
Luca Gabrielli ₁ , Monica Carril _{2,

3} , Daniel Padro ₂ , Fabrizio Mancin ₁

Affiliation

Nanoconjugates composed of gold nanoparticles (core diameter=1.9 nm) coated with thioundecyl‐d‐glucopyranosides and fluorinated phenylboronic acids can detect diol‐containing derivatives by means of ¹⁹F NMR spectroscopic analysis. The spectra of nanoconjugate solutions display broad signals due to the fast relaxation of the ¹⁹F nuclei caused by nanoparticle grafting. When dopamine is added, the formation of a boronate ester between the analyte and the fluorinated boronic acid causes the release of the latter in solution and consequent sharpening of the NMR signals. Dopamine can be selectively detected through magnetic resonance imaging (MRI) and NMR spectroscopic analysis with respect to glucose and galactose with a detection limit of 20 μm. The chemical shift of the released ester is diagnostic of the recognized analyte. Consequently, the sensor also enables the simultaneous detection of different analytes.

中文翻译：

多峰19F NMR多巴胺检测和成像，基于纳米粒子的位移分析

涂覆有金的纳米颗粒（芯直径= 1.9纳米）组成的纳米缀合物thioundecyl- d -glucopyranosides和氟化苯硼酸可以通过以下方式检测含二醇的衍生物¹⁹ F NMR光谱分析。纳米共轭溶液的光谱显示出宽泛的信号，这是由于纳米粒子接枝引起的¹⁹ F核快速松弛所致。当添加多巴胺时，在分析物和氟化硼酸之间形成硼酸酯会导致后者在溶液中的释放，从而使NMR信号锐化。可以通过磁共振成像（MRI）和NMR光谱分析法对葡萄糖和半乳糖选择性地检测多巴胺，检测限为20μm。释放的酯的化学位移可诊断出已识别的分析物。因此，该传感器还能够同时检测不同的分析物。

更新日期：2018-07-25

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