目前对角鲨烯生物作用的见解,Molecular Nutrition & Food Research

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目前对角鲨烯生物作用的见解
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-07-19 , DOI: 10.1002/mnfr.201800136
José M Lou-Bonafonte _{1,

2,

3} , Roberto Martínez-Beamonte _{2,

3,

4} , Teresa Sanclemente ₄ , Joaquín C Surra _{2,

3,

4} , Luis V Herrera-Marcos _{2,

5} , Javier Sanchez-Marco ₅ , Carmen Arnal _{2,

3,

6} , Jesús Osada _{2,

3,

5}

Affiliation

角鲨烯是一种在大量植物和其他来源中发现的三萜类化合物，自 1926 年首次报道以来具有悠久的研究传统。本文对过去 8 年发表的有关角鲨烯的研究进行了系统回顾。这些研究进一步支持了其在体内和体外的抗氧化、抗炎和抗动脉粥样硬化特性。此外，还报道了营养遗传型治疗的抗肿瘤作用，这取决于肿瘤代谢途径的失败。角鲨烯在细胞培养物、动物模型和人体中的生物利用度已经得到很好的证实，并且在这种亲脂性分子的细胞内转运方面取得了进一步的进展。角鲨烯在肝脏中积累并降低肝脏胆固醇和甘油三酯，这些作用是通过复杂的基因表达变化网络在转录和转录后水平发挥作用的。还研究了它在不同生物体液中的存在。角鲨烯与其他生物活性化合物的结合已被证明可以增强其多效性，并可能导致功能性食品和营养保健品的配方，以控制氧化应激，从而控制人类和兽医学中许多与年龄相关的疾病。

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Current Insights into the Biological Action of Squalene

Squalene is a triterpenic compound found in a large number of plants and other sources with a long tradition of research since it was first reported in 1926. Herein a systematic review of studies concerning squalene published in the last 8 years is presented. These studies have provided further support for its antioxidant, anti‐inflammatory, and anti‐atherosclerotic properties in vivo and in vitro. Moreover, an antineoplastic effect in nutrigenetic‐type treatments, which depends on the failing metabolic pathway of tumors, has also been reported. The bioavailability of squalene in cell cultures, animal models, and in humans has been well established, and further progress has been made in regard to the intracellular transport of this lipophilic molecule. Squalene accumulates in the liver and decreases hepatic cholesterol and triglycerides, with these actions being exerted via a complex network of changes in gene expression at both transcriptional and post‐transcriptional levels. Its presence in different biological fluids has also been studied. The combination of squalene with other bioactive compounds has been shown to enhance its pleiotropic properties and might lead to the formulation of functional foods and nutraceuticals to control oxidative stress and, therefore, numerous age‐related diseases in human and veterinary medicine.

更新日期：2018-07-19

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