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Design, Synthesis and Computational Studies of Novel Carbazole N‐phenylacetamide Hybrids as Potent Antibacterial, Anti‐inflammatory, and Antioxidant Agents
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2018-06-08 , DOI: 10.1002/jhet.3214
Shivarudrappa H. Pattanashetty 1 , K. M. Hosamani 1 , Arun Kashivishwanath Shettar 2 , R. Mohammed Shafeeulla 3
Affiliation  

The present study deals with the synthesis of N‐phenylacetamide‐functionalized carbazole derivatives and their antibacterial, anti‐inflammatory, and antioxidant assays. In vitro antibacterial studies of synthesized compounds shows prominent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. In addition, in silico molecular docking studies corroborated that the methyl substituent (3g), (3h), and (3i) showed promising activity with lower ∆G (kcal/mol) values. This study envisages that these compounds can serve as a new leading template in the chemotherapy of various bacterial ailments.

中文翻译:

新型咔唑N-苯基乙酰胺杂化物作为有效的抗菌,消炎和抗氧化剂的设计,合成和计算研究

本研究涉及N-苯基乙酰胺官能化的咔唑衍生物的合成及其抗菌,消炎和抗氧化剂测定。合成化合物的体外抗菌研究显示对金黄色葡萄球菌枯草芽孢杆菌大肠杆菌铜绿假单胞菌具有显着活性。此外,计算机分子对接研究证实了甲基取代基(3g),(3h)和(3i)在较低的∆G(kcal / mol)值下显示出令人鼓舞的活性。这项研究设想这些化合物可以作为各种细菌性疾病的化学治疗的新的领先模板。
更新日期:2018-06-08
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