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Dual-phosphorescent Iridium(III) Complexes Extending Oxygen Sensing from Hypoxia to Hyperoxia
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-06-06 , DOI: 10.1021/jacs.8b02492 Kenneth Yin Zhang 1 , Pengli Gao 1 , Guanglan Sun 1 , Taiwei Zhang 1 , Xiangling Li 1 , Shujuan Liu 1 , Qiang Zhao 1 , Kenneth Kam-Wing Lo 2 , Wei Huang 1, 3
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-06-06 , DOI: 10.1021/jacs.8b02492 Kenneth Yin Zhang 1 , Pengli Gao 1 , Guanglan Sun 1 , Taiwei Zhang 1 , Xiangling Li 1 , Shujuan Liu 1 , Qiang Zhao 1 , Kenneth Kam-Wing Lo 2 , Wei Huang 1, 3
Affiliation
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Hypoxia and hyperoxia, referring to states of biological tissues in which oxygen supply is in sufficient and excessive, respectively, are often pathological conditions. Many luminescent oxygen probes have been developed for imaging intracellular and in vivo hypoxia, but their sensitivity toward hyperoxia becomes very low. Here we report a series of iridium(III) complexes in which limited internal conversion between two excited states results in dual phosphorescence from two different excited states upon excitation at a single wavelength. Structural manipulation of the complexes allows rational tuning of the dual-phosphorescence properties and the spectral profile response of the complexes toward oxygen. By manipulating the efficiency of internal conversion between the two emissive states, we obtained a complex exhibiting naked-eye distinguishable green, orange, and red emission in aqueous buffer solution under an atmosphere of N2, air, and O2, respectively. This complex is used for intracellular and in vivo oxygen sensing not only in the hypoxic region but also in normoxic and hyperoxic intervals. To the best of our knowledge, this is the first example of using a molecular probe for simultaneous bioimaging of hypoxia and hyperoxia.
中文翻译：
双磷光铱 (III) 配合物将氧感应从缺氧扩展到高氧
缺氧和高氧分别是指生物组织供氧充足和过量的状态，往往是病理状态。许多发光氧探针已被开发用于成像细胞内和体内缺氧，但它们对高氧的敏感性变得非常低。在这里，我们报告了一系列铱 (III) 配合物，其中两个激发态之间的有限内部转换导致在单个波长激发时来自两个不同激发态的双重磷光。复合物的结构操作允许合理调整双磷光特性和复合物对氧的光谱曲线响应。通过操纵两个发射状态之间的内部转换效率，我们在 N2、空气和 O2 气氛下分别在水性缓冲溶液中获得了一种复合物，该复合物表现出肉眼可区分的绿色、橙色和红色发射。这种复合物不仅用于缺氧区域的细胞内和体内氧传感，而且用于常氧和高氧区间。据我们所知，这是使用分子探针同时对缺氧和高氧进行生物成像的第一个例子。
更新日期：2018-06-06
中文翻译：
双磷光铱 (III) 配合物将氧感应从缺氧扩展到高氧
缺氧和高氧分别是指生物组织供氧充足和过量的状态，往往是病理状态。许多发光氧探针已被开发用于成像细胞内和体内缺氧，但它们对高氧的敏感性变得非常低。在这里，我们报告了一系列铱 (III) 配合物，其中两个激发态之间的有限内部转换导致在单个波长激发时来自两个不同激发态的双重磷光。复合物的结构操作允许合理调整双磷光特性和复合物对氧的光谱曲线响应。通过操纵两个发射状态之间的内部转换效率，我们在 N2、空气和 O2 气氛下分别在水性缓冲溶液中获得了一种复合物，该复合物表现出肉眼可区分的绿色、橙色和红色发射。这种复合物不仅用于缺氧区域的细胞内和体内氧传感，而且用于常氧和高氧区间。据我们所知，这是使用分子探针同时对缺氧和高氧进行生物成像的第一个例子。
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