Microspheres of Carboxymethyl Chitosan, Sodium Alginate, and Collagen as a Hemostatic Agent in Vivo,ACS Biomaterials Science & Engineering

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Microspheres of Carboxymethyl Chitosan, Sodium Alginate, and Collagen as a Hemostatic Agent in Vivo
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-06-06 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00453
Jia Jin _{1,

2} , Zhixiao Ji ₁ , Ming Xu ₁ , Chenyu Liu ₁ , Xiaoqing Ye ₁ , Weiyao Zhang ₁ , Si Li _{1,

2} , Dan Wang _{1,

2} , Wenping Zhang _{1,

2} , Jianqing Chen _{1,

2} , Fei Ye ₁ , Zhengbing Lv _{1,

2}

Affiliation

In the search for biocompatible composite microspheres to be used as a hemostatic agent, in a previous study, we designed a novel biomaterial, consisting of composite microspheres containing three natural biological ingredients, carboxymethyl chitosan, sodium alginate and collagen (CSCM). Furthermore, the chemical and physical properties, hemostatic ability, biocompatibility and cytotoxicity were investigated in vitro. In this work, the in vivo hemostatic performance, wound healing, hemocompatibility, histocompatibility, and biodegradability were evaluated by a series of experiments. The results showed that CSCM could both stop bleeding and enhance healing efficiency by accelerating the clotting and the wound closure rate, suggesting that CSCM acts as a hemostat, and enhances wound healing. In addition, the CSCM material had negligible intracutaneous stimulation reactions and no obvious hemolytic reactions. More importantly, CSCM can be degraded in vivo without significant impacts on physiology, biochemistry, and organization. Thus, CSCM may be a useful tool to stop bleeding in emergency conditions in both military and civilian settings.

中文翻译：

羧甲基壳聚糖，海藻酸钠和胶原蛋白作为体内止血剂的微球

在寻找可用作止血剂的生物相容性复合微球时，在先前的研究中，我们设计了一种新型的生物材料，该复合材料由包含三种天然生物成分，羧甲基壳聚糖，藻酸钠和胶原蛋白（CSCM）的复合微球组成。此外，在体外研究了化学和物理性质，止血能力，生物相容性和细胞毒性。在这项工作中，通过一系列实验评估了体内止血性能，伤口愈合，血液相容性，组织相容性和生物降解性。结果表明，CSCM可以通过加速凝血和伤口闭合率来止血并提高治愈效率，这表明CSCM可以起到止血作用，并可以促进伤口愈合。此外，CSCM材料的皮内刺激反应微不足道，没有明显的溶血反应。更重要的是，CSCM可以在体内降解，而不会对生理，生物化学和组织产生重大影响。因此，CSCM可能是在军事和民用环境中在紧急情况下制止出血的有用工具。

更新日期：2018-06-06

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