Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-06-06 , DOI: 10.1002/adfm.201801386
Guopu Chen ₁ , Yunru Yu ₂ , Xiuwen Wu ₁ , Gefei Wang ₁ , Jianan Ren ₁ , Yuanjin Zhao ₂

Affiliation

Inspired by the coordinated multiple healing mechanism of the organism, a four‐armed benzaldehyde‐terminated polyethylene glycol and dodecyl‐modified chitosan hybrid hydrogel with vascular endothelial growth factor (VEGF) encapsulation are presented for efficient and versatile wound healing. The hybrid hydrogel is formed through the reversible Schiff base and possesses self‐healing capability. As the dodecyl tails can insert themselves into and be anchored onto the lipid bilayer of the cell membrane, the hybrid hydrogel has outstanding tissue adhesion, blood cell coagulation and hemostasis, anti‐infection, and cell recruitment functions. Moreover, by loading in and controllably releasing VEGF from the hybrid hydrogel, the processes of cell proliferation and tissue remodeling in the wound bed can be significantly improved. Based on an in vivo study of the multifunctional hybrid hydrogel, it is demonstrated that acute tissue injuries such as vessel bleeding and liver bleeding can be repaired immediately because of the outstanding adhesion and hemostasis features of the hydrogel. Moreover, the chronic wound‐healing process of an infectious full‐thickness skin defect model can also be significantly enhanced by promoting angiogenesis, collagen deposition, macrophage polarization, and granulation tissue formation. Thus, this multifunctional hybrid hydrogel is potentially valuable for clinical applications.

中文翻译：

受生物启发的多功能混合水凝胶促进伤口愈合

受生物体协调的多种愈合机制的启发，提出了一种四臂苯甲醛封端的聚乙二醇和十二烷基改性的壳聚糖杂化水凝胶，带有血管内皮生长因子（VEGF）封装，可实现高效，多用途的伤口愈合。杂化水凝胶是通过可逆席夫碱形成的，具有自愈能力。由于十二烷基尾巴可以插入并固定在细胞膜的脂质双层上，因此杂化水凝胶具有出色的组织粘附性，血细胞凝结和止血，抗感染和细胞募集功能。此外，通过加载和可控地从杂合水凝胶中释放VEGF，伤口床中的细胞增殖和组织重塑过程可以得到显着改善。基于对多功能混合水凝胶的体内研究，证明了由于水凝胶出色的粘附和止血功能，可以立即修复急性组织损伤，例如血管出血和肝出血。此外，传染性全层皮肤缺损模型的慢性伤口愈合过程也可以通过促进血管生成，胶原蛋白沉积，巨噬细胞极化和肉芽组织形成而得到显着增强。因此，这种多功能混合水凝胶对于临床应用具有潜在的价值。通过促进血管生成，胶原蛋白沉积，巨噬细胞极化和肉芽组织形成，传染性全层皮肤缺损模型的慢性伤口愈合过程也可以得到显着增强。因此，这种多功能混合水凝胶对于临床应用具有潜在的价值。通过促进血管生成，胶原蛋白沉积，巨噬细胞极化和肉芽组织形成，传染性全层皮肤缺损模型的慢性伤口愈合过程也可以得到显着增强。因此，这种多功能混合水凝胶对于临床应用具有潜在的价值。

更新日期：2018-06-06

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南